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The In ovo CAM-assay as a Xenograft Model for Sarcoma

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Published on: July 17, 2013

Clear cell chondrosarcoma: an ultrastructural study.

Naoto Kuroda¹, Toshiharu Sogoh, Masahiko Ohara

¹Department of Diagnostic Pathology, Kochi Red Cross Hospital, Kochi 780-8562, Japan. kurochankochi@yahoo.co.jp

Medical Molecular Morphology

|September 29, 2009

Summary

Clear cell chondrosarcoma (CCC) is a rare bone tumor. Ultrastructural analysis suggests clear cells in CCC exhibit chondrocyte differentiation, with glycogen accumulation contributing to their clear appearance.

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Staining and High-Resolution Imaging of Three-Dimensional Organoid and Spheroid Models

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Published on: March 27, 2021

Area of Science:

Oncology
Pathology
Cell Biology

Background:

Clear cell chondrosarcoma (CCC) is an uncommon bone neoplasm.
This report details a specific case of CCC in a 67-year-old Japanese man.

Observation:

The patient presented with a year of right hip joint pain.
Histological examination of the resected right femoral bone confirmed CCC.
Ultrastructural analysis revealed clear neoplastic cells with perinuclear organelle concentration.

Findings:

Clear neoplastic cells contained abundant glycogen particles, particularly in organelle-depleted cytoplasm.
Mitochondria, Golgi complex, actin filaments, and rough endoplasmic reticulum were observed within clear cells.
Well-developed microvilli were present on the neoplastic cell surfaces, resembling normal chondrocytes.

Implications:

Ultrastructural findings support chondrocyte differentiation in clear cells of CCC.
The accumulation of glycogen and the relative lack of organelles in specific cytoplasmic areas likely contribute to the characteristic clear cell morphology.
This case adds to the understanding of the cellular characteristics and potential differentiation pathways in clear cell chondrosarcoma.