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Updated: Jun 20, 2026

Multimodal Approach to Assess Bone Regeneration and Scaffold Performance
Published on: February 13, 2026
Synchrotron X-ray imaging via ultra-small-angle scattering: principles of quantitative analysis and application in
Sérgio L Morelhão1, Paulo G Coelho, Marcelo G Hönnicke
1Instituto de Física, Universidade de São Paulo, São Paulo, SP, Brazil. morelhao@if.usp.br
Abstract:
Optimized experimental conditions for extracting accurate information at subpixel length scales from analyzer-based X-ray imaging were obtained and applied to investigate bone regeneration by means of synthetic beta-TCP grafting materials in a rat calvaria model. The results showed a 30% growth in the particulate size due to bone ongrowth/ingrowth within the critical size defect over a 1-month healing period.
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