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Related Concept Videos

Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
Distinctive Features of Adult Stem Cells vs Cancer Stem Cells01:18

Distinctive Features of Adult Stem Cells vs Cancer Stem Cells

A stem cell is an unspecialized cell that can divide without limit as needed and can, under specific conditions, differentiate into specialized cells.
Adult stem cells
Adult stem cells are tissue-specific; hence, they divide to develop the tissue from which they originate. One type of adult stem cell is the epithelial stem cell, which gives rise to the keratinocytes in the multiple layers of epithelial cells in the epidermis of the skin. Adult bone marrow has three distinct types of stem cells:...
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...
Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their access...
Stem Cell Culture01:17

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...

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Related Experiment Video

Updated: Jun 20, 2026

Processing of Primary Brain Tumor Tissue for Stem Cell Assays and Flow Sorting
08:14

Processing of Primary Brain Tumor Tissue for Stem Cell Assays and Flow Sorting

Published on: September 25, 2012

Brain cancer stem cells.

Sara G M Piccirillo1, Elena Binda, Roberta Fiocco

  • 1Department of Biosciences and Biotechnology, University of Milan Bicocca, Piazza della Scienza 2, Building U3, 20126 Milan, Italy.

Journal of Molecular Medicine (Berlin, Germany)
|September 29, 2009
PubMed
Summary
This summary is machine-generated.

Cancer stem cells (CSCs) drive brain tumor growth and recurrence. Targeting these glioblastoma stem-like cells (GBSCs) offers a promising therapeutic strategy for malignant brain tumors.

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Evaluation of Cancer Stem Cell Migration Using Compartmentalizing Microfluidic Devices and Live Cell Imaging
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Evaluation of Cancer Stem Cell Migration Using Compartmentalizing Microfluidic Devices and Live Cell Imaging

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Optimization of High Grade Glioma Cell Culture from Surgical Specimens for Use in Clinically Relevant Animal Models and 3D Immunochemistry
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Evaluation of Cancer Stem Cell Migration Using Compartmentalizing Microfluidic Devices and Live Cell Imaging
09:36

Evaluation of Cancer Stem Cell Migration Using Compartmentalizing Microfluidic Devices and Live Cell Imaging

Published on: December 23, 2011

Area of Science:

  • Neuro-oncology
  • Cancer Stem Cell Biology
  • Tumorigenesis

Background:

  • Cancers exhibit cellular heterogeneity, including cancer stem cells (CSCs).
  • CSCs are identified in brain tumors like glioblastoma multiforme (GBM), medulloblastoma, and ependymoma.
  • Glioblastoma stem-like cells (GBSCs) possess self-renewal and differentiation capabilities, mirroring normal neural stem cells.

Purpose of the Study:

  • To review the role of CSCs in brain tumor development.
  • To highlight GBSCs as potential therapeutic targets.
  • To explore molecular mechanisms regulating CSC tumorigenicity.

Main Methods:

  • Literature review of CSC research in brain tumors.
  • Analysis of GBSC characteristics and tumorigenic potential.
  • Discussion of therapeutic implications.

Main Results:

  • GBSCs self-renew and differentiate into diverse neural lineages.
  • Transplanted GBSCs form secondary tumors mimicking human pathology.
  • Neural stem cell regulatory systems influence GBSC tumorigenicity.

Conclusions:

  • Identifying CSC markers and mechanisms is crucial for targeted therapies.
  • GBSCs represent a key target for brain tumor treatment.
  • Understanding CSCs advances novel therapeutic strategies for brain cancers.