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Updated: Jun 20, 2026

Membrane-SPINE: A Biochemical Tool to Identify Protein-protein Interactions of Membrane Proteins In Vivo

Membrane-SPINE: A Biochemical Tool to Identify Protein-protein Interactions of Membrane Proteins In Vivo

Published on: November 7, 2013

MPEx: a tool for exploring membrane proteins.

Craig Snider¹, Sajith Jayasinghe, Kalina Hristova

¹Department of Physiology and Biophysics, Center for Biomembrane Systems, University of California, Irvine, California 92697-4560, USA.

Protein Science : a Publication of the Protein Society

|September 29, 2009

Summary

Membrane Protein Explorer (MPEx) is a versatile software tool for analyzing membrane protein sequences using hydropathy plots. It aids in identifying transmembrane regions and designing membrane-active peptides.

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Last Updated: Jun 20, 2026

Membrane-SPINE: A Biochemical Tool to Identify Protein-protein Interactions of Membrane Proteins In Vivo

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Published on: November 7, 2013

Method to Visualize and Analyze Membrane Interacting Proteins by Transmission Electron Microscopy

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Multimer-PAGE: A Method for Capturing and Resolving Protein Complexes in Biological Samples

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Published on: May 5, 2017

Area of Science:

Biochemistry
Structural Biology
Bioinformatics

Background:

Hydropathy plot methods are essential for early-stage membrane protein research.
Analyzing membrane protein sequences is crucial for understanding their function.

Purpose of the Study:

To introduce Membrane Protein Explorer (MPEx), a refined hydropathy-plot software.
To provide a versatile tool for membrane protein sequence analysis.

Main Methods:

Utilizes experiment-based physical and biological hydrophobicity scales.
MPEx is an interactive Java Web Start application.

Main Results:

Facilitates characterization and identification of transmembrane regions.
Enables examination of sequence mutation consequences.
Aids in the design of membrane-active peptides.

Conclusions:

MPEx is a valuable and accessible tool for membrane protein research.
The software enhances the analysis of membrane protein sequences and peptide design.