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Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
Cancer Vaccines01:30

Cancer Vaccines

Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Treatment Resistent Cancers02:56

Treatment Resistent Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...

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Updated: Jun 20, 2026

Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo
12:42

Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo

Published on: January 7, 2019

Vector vaccination and vector targeted chemotherapy in solid tumors.

H Akbulut1, Y Tang, A Deisseroth

  • 1Ankara University School of Medicine, Department of Medical Oncology, Cebeci Hospital, Ankara, Turkey. akbulut@medicine.ankara.edu.tr

Journal of B.U.ON. : Official Journal of the Balkan Union of Oncology
|September 29, 2009
PubMed
Summary
This summary is machine-generated.

Gene therapy offers promising cancer treatment options, including tumor suppressor gene introduction and immune response modulation. Combining gene therapy with conventional treatments shows encouraging results in early trials.

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Area of Science:

  • Oncology
  • Molecular Biology
  • Immunology

Background:

  • Gene therapy is a promising approach in cancer treatment.
  • Current strategies include introducing tumor suppressor genes, modulating immune responses, and suicide gene therapy.
  • Early clinical trials for cancer gene therapy have shown limited success.

Purpose of the Study:

  • To review current gene therapy strategies for cancer.
  • To evaluate the efficacy of combining gene therapy with conventional treatments.

Main Methods:

  • Review of existing gene therapy techniques for cancer.
  • Analysis of experimental and early clinical trial data.

Main Results:

  • Gene therapy modalities focus on tumor suppressor genes, immune modulation, and suicide gene therapy.
  • Early clinical trials have not yielded highly encouraging results.
  • Combination therapies (gene therapy + chemotherapy/immunotherapy/radiotherapy) show promise.

Conclusions:

  • Gene therapy holds potential for cancer treatment.
  • Combination strategies are crucial for improving outcomes.
  • Further research and clinical trials are needed to optimize gene therapy efficacy.