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Electrophoretic Delivery of γ-aminobutyric Acid (GABA) into Epileptic Focus Prevents Seizures in Mice
Published on: May 16, 2019
[Epilepsy from seizure to care]
Cees A van Donselaar1, J A Hans Carpay
1Maasstad Ziekenhuis, afd. Neurologie, Rotterdam, The Netherlands. donselaarc@maasstadziekenhuis.nl
Nederlands Tijdschrift Voor Geneeskunde
|September 30, 2009
Summary
Epilepsy affects 5 in 1000 people, with diagnosis often incorrect. Specialized centers offer accurate diagnosis and treatment, including medication, surgery, or vagus nerve stimulation, to improve seizure control and quality of life.
Area of Science:
- Neurology
- Clinical Medicine
Context:
- Epilepsy is a common neurological disorder with a prevalence of 5:1000 in the Netherlands.
- Diagnosis is frequently based on clinical grounds and can be inaccurate.
- Referral to specialized centers is crucial for accurate diagnosis through seizure registration, EEG, and video recording.
Purpose:
- To outline the diagnostic and therapeutic approaches for epilepsy.
- To highlight the effectiveness of various treatment modalities.
- To emphasize the importance of optimizing treatment for improved patient quality of life.
Summary:
- Anti-epileptic drugs (AEDs) are effective in 60-70% of patients.
- For treatment-resistant cases, surgical intervention, particularly for temporal epilepsy, offers significant symptom resolution.
- Vagus nerve stimulation is an alternative for difficult-to-manage medication cases.
Impact:
- Accurate diagnosis and tailored treatment strategies can significantly improve seizure control.
- Addressing medication side effects and patient-imposed limitations enhances the quality of life for individuals with epilepsy.
- Specialized epilepsy centers play a vital role in managing complex cases and optimizing patient outcomes.
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