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Published on: June 26, 2020
[Herpes simplex virus hepatitis; rare in immunocompetent patients]
Leyla Ozokcu1, Leo M de Bruijckere, Jan Jansen
1Ziekenhuis Walcheren, Afd. Interne Geneeskunde, Vlissingen, The Netherlands.
Nederlands Tijdschrift Voor Geneeskunde
|September 30, 2009
Summary
Herpes simplex virus (HSV) can cause rare but severe viral hepatitis in adults. Prompt diagnosis and antiviral treatment with acyclovir led to a full recovery in this case.
Area of Science:
- Hepatology
- Virology
- Infectious Diseases
Background:
- Herpes simplex virus (HSV) is a common human pathogen.
- HSV is an uncommon cause of viral hepatitis, particularly in immunocompetent adults.
- Viral hepatitis typically presents with elevated liver enzymes, jaundice, and abdominal discomfort.
Observation:
- A 42-year-old woman presented with fever and abdominal pain suggestive of peritoneal irritation.
- Diagnostic laparoscopy revealed hepatic lesions.
- Liver biopsy confirmed hepatitis attributed to herpes simplex virus (HSV).
Findings:
- Histopathological analysis identified HSV as the causative agent of hepatitis.
- The patient received intravenous acyclovir for treatment.
- Clinical improvement and recovery were observed following antiviral therapy.
Implications:
- This case highlights HSV as a potential cause of acute hepatitis, even in the absence of typical herpetic symptoms.
- Early diagnosis and management with antiviral medications are crucial for improving outcomes in HSV hepatitis.
- Recognizing this rare etiology is important due to its potential for high mortality if left untreated.
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