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Related Experiment Video

Updated: Jun 20, 2026

Diffuse Optical Spectroscopy for the Quantitative Assessment of Acute Ionizing Radiation Induced Skin Toxicity Using a Mouse Model

Diffuse Optical Spectroscopy for the Quantitative Assessment of Acute Ionizing Radiation Induced Skin Toxicity Using a Mouse Model

Published on: May 27, 2016

[Diagnostic image; a man with severe radiation dermatitis].

Geert O R J Janssens¹, Carla M L van Herpen

¹Universitair Medisch Centrum St Radboud, Afd. Radiotherapie, Nijmegen, The Netherlands. g.janssens@rther.umcn.nl

Nederlands Tijdschrift Voor Geneeskunde

|September 30, 2009

Summary

Concurrent radiotherapy and cetuximab treatment for tongue cancer can cause severe skin reactions like moist desquamation and necrosis. Discontinuing cetuximab led to the healing of these adverse skin events.

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Last Updated: Jun 20, 2026

Diffuse Optical Spectroscopy for the Quantitative Assessment of Acute Ionizing Radiation Induced Skin Toxicity Using a Mouse Model

Diffuse Optical Spectroscopy for the Quantitative Assessment of Acute Ionizing Radiation Induced Skin Toxicity Using a Mouse Model

Published on: May 27, 2016

Area of Science:

Oncology
Dermatology
Radiation Oncology

Background:

Head and neck cancers, including tongue cancer, are often treated with concurrent chemoradiotherapy.
Cetuximab, a monoclonal antibody, is frequently used in combination with radiation therapy for certain head and neck cancers.

Observation:

A 51-year-old male patient undergoing concurrent radiotherapy and cetuximab for tongue cancer experienced significant skin toxicity.
The patient developed moist desquamation, spontaneous bleeding, and skin necrosis after receiving 42 Gy of radiation.

Findings:

The observed skin adverse events were directly linked to the combined treatment regimen.
Cessation of cetuximab therapy resulted in the resolution of the patient's skin complications.

Implications:

This case highlights the potential for severe cutaneous toxicity when combining radiotherapy with cetuximab.
Careful monitoring and consideration of treatment modification, such as cetuximab discontinuation, may be necessary to manage radiation-induced skin damage.
Further research into managing skin toxicities in patients receiving concurrent chemoradiotherapy is warranted.