Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Drug Dosing: Geriatric Patients

Drug Dosing: Geriatric Patients

Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...

Pharmacodynamics in Geriatric Patients: Effects of Age

Pharmacodynamics in Geriatric Patients: Effects of Age

Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are not...

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism

Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Optical Properties of MoSe<sub>2</sub> Monolayer Implanted with Ultra-Low-Energy Cr Ions.

ACS applied materials & interfaces·2023

Same author

Quasiparticle Self-Consistent <i>GW</i> Study of Simple Metals.

Nanomaterials (Basel, Switzerland)·2022

Same author

Patient assessment and feasibility of treatment in older patients with cancer: results from the IN-GHO<sup>®</sup> Registry.

Journal of cancer research and clinical oncology·2021

Same author

Plasmons in MoS<sub>2</sub> studied via experimental and theoretical correlation of energy loss spectra.

Journal of microscopy·2020

Same author

[Challenges of implementing a geriatric trauma network : A regional structure].

Der Unfallchirurg·2017

Same author

[The company Willmar Schwabe in the Nazi era].

Medizin, Gesellschaft, und Geschichte : Jahrbuch des Instituts fur Geschichte der Medizin der Robert Bosch Stiftung·2016

Search research articles

Related Experiment Video

Updated: Jun 20, 2026

Oral Health Assessment by Lay Personnel for Older Adults

Oral Health Assessment by Lay Personnel for Older Adults

Published on: February 2, 2020

[The geriatric assessment].

Christoph Friedrich¹, Beate S Schultheis, Ludger Pientka

¹Klinik für Altersmedizin und Frührehabilitation, Klinikum der Ruhr-Universitat Bochum, Herne, Deutschland.

|September 30, 2009

Summary

As cancer affects more older adults, geriatric assessment helps oncologists tailor treatments by identifying patient fitness and risks. This approach is feasible and improves outcomes, though cancer-specific tools are still needed.

Area of Science:

Geriatric oncology
Cancer epidemiology
Patient assessment

Context:

Increasing number of elderly cancer patients due to demographic shifts.
Heterogeneity in older cancer patients compared to younger counterparts.
Need for tailored treatment strategies for diverse geriatric populations.

Purpose:

To highlight the importance of geriatric assessment in oncology.
To demonstrate the utility of geriatric assessment in identifying patient fitness and risks.
To underscore the feasibility and positive impact of geriatric assessment in clinical practice.

Summary:

Geriatric assessment is crucial for managing the growing population of elderly cancer patients.
This diagnostic tool helps oncologists differentiate between fit and at-risk elderly patients.

More Related Videos

Assessment of Dependence in Activities of Daily Living Among Older Patients in an Acute Care Unit

Assessment of Dependence in Activities of Daily Living Among Older Patients in an Acute Care Unit

Published on: September 30, 2020

Highlighting and Reducing the Impact of Negative Aging Stereotypes During Older Adults' Cognitive Testing

Highlighting and Reducing the Impact of Negative Aging Stereotypes During Older Adults' Cognitive Testing

Published on: January 24, 2020

Related Experiment Videos

Last Updated: Jun 20, 2026

Oral Health Assessment by Lay Personnel for Older Adults

Oral Health Assessment by Lay Personnel for Older Adults

Published on: February 2, 2020

Assessment of Dependence in Activities of Daily Living Among Older Patients in an Acute Care Unit

Assessment of Dependence in Activities of Daily Living Among Older Patients in an Acute Care Unit

Published on: September 30, 2020

Highlighting and Reducing the Impact of Negative Aging Stereotypes During Older Adults' Cognitive Testing

Highlighting and Reducing the Impact of Negative Aging Stereotypes During Older Adults' Cognitive Testing

Published on: January 24, 2020

It enables personalized treatment plans, improving patient outcomes and reducing complications.

Impact:

Geriatric assessment improves treatment strategy efficacy in elderly cancer patients.
The approach is proven feasible for integration into daily oncological practice.
Further development of cancer-specific geriatric assessment tools is warranted.