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Preparation Of Neovascular Tissues from Human Glioma Tissues for Quantitative Proteomics Analysis of Tumor Angiogenesis
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Primetime for antiangiogenic therapy.

Ghazaleh Tabatabai1, Roger Stupp

  • 1Department of Neurology, University Hospital Zurich, Zurich, Switzerland. ghazaleh.tabatabai@usz.ch

Current Opinion in Neurology
|September 30, 2009
PubMed
Summary
This summary is machine-generated.

Angiogenesis inhibitors show promise for treating gliomas, but patient survival remains poor. Further research into combination therapies is needed to overcome treatment resistance and improve outcomes.

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Area of Science:

  • Neuro-oncology
  • Cancer therapy
  • Molecular biology

Background:

  • Gliomas are aggressive brain tumors with limited treatment options.
  • Angiogenesis plays a critical role in glioma growth and progression.
  • Antiangiogenic therapies target tumor vasculature to inhibit growth.

Purpose of the Study:

  • To review current clinical experience with angiogenesis inhibitors in glioma treatment.
  • To discuss mechanisms of resistance to antiangiogenic therapy.
  • To explore future therapeutic strategies for malignant gliomas.

Main Methods:

  • Review of recent clinical trials involving angiogenesis inhibitors for gliomas.
  • Analysis of mechanisms of resistance, including phenotypic changes and alternative pathways.
  • Discussion of combination therapy approaches.

Main Results:

  • Bevacizumab is approved for recurrent glioblastomas, with promising agents under investigation.
  • Radiological response rates are high, but often short-lived.
  • Tumor recurrence is associated with increased invasiveness and resistance.
  • Observed effects may be due to blood-brain barrier normalization rather than direct antitumor activity.

Conclusions:

  • Antiangiogenic therapy offers modest benefits in glioma treatment, with poor overall survival.
  • Mechanisms of resistance include induction of invasive phenotypes and activation of proangiogenic pathways.
  • Combination regimens targeting multiple pathways are crucial for overcoming resistance.
  • Future research should focus on developing novel strategies to enhance the efficacy of antiangiogenic therapy in malignant gliomas.