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Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
Published on: June 8, 2022
Serum free light chain assessment in monoclonal gammopathy and kidney disease
Colin A Hutchison1, Kolitha Basnayake, Paul Cockwell
1Renal Institute of Birmingham, University Hospital Birmingham, and Department of Infection and Immunity, University of Birmingham, Birmingham, UK. c.a.hutchison@bham.ac.uk
Abstract:
Abnormalities of immunoglobulin free light chains (FLCs) are frequently present in patients with monoclonal gammopathies and can cause kidney disease. The recent introduction of highly sensitive immunoassays that measure FLCs to levels below those present in normal individuals has provided a new tool for diagnosis and management in this setting. Here, we review the biology of FLC production in health and disease, and the utility of FLC immunoassays in the assessment of monoclonal gammopathies in kidney disease.
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