Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Video

Updated: Jun 20, 2026

Multimodal Cross-Device and Marker-Free Co-Registration of Preclinical Imaging Modalities

Multimodal Cross-Device and Marker-Free Co-Registration of Preclinical Imaging Modalities

Published on: October 27, 2023

Local flip angle correction for improved volume T1-quantification in three-dimensional dGEMRIC using the Look-Locker

Carl Siversson¹, Carl-Johan Tiderius, Leif Dahlberg

¹Department of Radiation Physics, Lund University, Malmö, Sweden. carl.siversson@med.lu.se

Journal of Magnetic Resonance Imaging : JMRI

|September 30, 2009

Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Quantification of pituitary 5-HT<sub>1B</sub> receptors with positron emission tomography: Negligible specific binding despite conspicuous uptake.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism·2026

Same author

Interventional Vitamin Mix Glaucoma Study (IVMGS): study protocol for a prospective, randomized, two-arm, single-center trial in existing glaucoma patients.

Trials·2025

Same author

Defining an Ageing-Related Pathology, Disease or Syndrome: International Consensus Statement.

medRxiv : the preprint server for health sciences·2024

Same author

Snow cover duration in northern Finland and the influence of key variables through a conceptual framework based on observed variations in snow depth.

The Science of the total environment·2023

Same author

Associations Between Cognition and Serotonin 1B Receptor Availability in Healthy Volunteers: A [11C]AZ10419369 Positron Emission Tomography Study.

The international journal of neuropsychopharmacology·2022

Same author

Is good muscle function a protective factor for early signs of knee osteoarthritis after anterior cruciate ligament reconstruction? The SHIELD cohort study protocol.

Osteoarthritis and cartilage open·2022

A new method improves three-dimensional Look-Locker (3D-LL) T1 quantification by correcting for flip angle variations. This technique provides accurate T1 values in vivo for delayed Gadolinium Enhanced MRI of Cartilage (dGEMRIC) studies.

Area of Science:

Magnetic Resonance Imaging (MRI)
Quantitative MRI
Biomedical Engineering

Background:

Accurate T1 quantification is crucial for MRI-based diagnostics.
Three-dimensional Look-Locker (3D-LL) sequences offer efficient T1 mapping but are sensitive to flip angle (FA) variations.
Existing methods struggle with FA inhomogeneity, leading to inaccurate T1 values, particularly in specific imaging slices.

Purpose of the Study:

To develop and evaluate a novel method for T1 quantification using 3D-LL that corrects for local FA variations.
To ensure accurate T1 measurements independent of FA inhomogeneity across all imaging slices.
To validate the proposed method in phantom studies and in vivo for delayed Gadolinium Enhanced MRI of Cartilage (dGEMRIC) applications.

Main Methods:

More Related Videos

Quantitative Assessment Protocol for Facial Soft Tissue Volumetric Changes with Stereophotogrammetry

Quantitative Assessment Protocol for Facial Soft Tissue Volumetric Changes with Stereophotogrammetry

Published on: December 9, 2025

Quantifying Intermembrane Distances with Serial Image Dilations

Quantifying Intermembrane Distances with Serial Image Dilations

Published on: September 28, 2018

Related Experiment Videos

Last Updated: Jun 20, 2026

Multimodal Cross-Device and Marker-Free Co-Registration of Preclinical Imaging Modalities

Multimodal Cross-Device and Marker-Free Co-Registration of Preclinical Imaging Modalities

Published on: October 27, 2023

Quantitative Assessment Protocol for Facial Soft Tissue Volumetric Changes with Stereophotogrammetry

Quantitative Assessment Protocol for Facial Soft Tissue Volumetric Changes with Stereophotogrammetry

Published on: December 9, 2025

Quantifying Intermembrane Distances with Serial Image Dilations

Quantifying Intermembrane Distances with Serial Image Dilations

Published on: September 28, 2018

T1 values were measured using 3D-LL sequences with both local FA correction and a precalculated FA slice profile.

Standard constant FA correction was compared against these advanced methods.

The gold standard for comparison was T1 measured using two-dimensional Inversion Recovery (2D-IR) in phantom and in vivo (femur condyles) studies involving 33 subjects.

Main Results:

Standard constant FA correction resulted in significant T1 errors (109.1 ms in vivo), especially in outer slices due to slice-dependent FA.
Local FA correction showed excellent phantom results (<5% deviation from 2D-IR) but lower in vivo performance (-57.5 ms systematic error), potentially due to inversion imperfections.
Precalculated FA correction demonstrated robust performance in vivo with a minimal systematic error of 13.3 ms.

Conclusions:

The precalculated FA correction method enhances the robustness of 3D-LL T1 quantification.
This advanced method enables reliable in vivo dGEMRIC imaging, even when acquiring data outside the central slices.
The findings support the clinical utility of 3D-LL for accurate T1 mapping in cartilage.