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The dichotomous distribution of gastrinomas
M P Sawicki1, T J Howard, M Dalton
1Department of Surgery, UCLA School of Medicine.
Archives of Surgery (Chicago, Ill. : 1960)
|December 11, 1990
Summary
Most sporadic gastrinomas (85%) are found to the right of the superior mesenteric artery, unlike insulinomas and glucagonomas. This right-sided location suggests a common origin for gastrinomas, including rare ovarian and renal tumors.
Area of Science:
- Endocrinology
- Surgical Oncology
- Gastroenterology
Background:
- Sporadic gastrinomas, a type of neuroendocrine tumor, exhibit a distinct anatomical distribution.
- Insulinomas and glucagonomas, other pancreatic neuroendocrine tumors, are typically located to the left of the superior mesenteric artery.
Purpose of the Study:
- To investigate the anatomical location of sporadic gastrinomas.
- To determine if extrapancreatic gastrinomas share a similar right-sided location.
- To explore the potential common origin of gastrinomas based on their anatomical distribution.
Main Methods:
- Retrospective analysis of 47 sporadic gastrinomas.
- Literature review of extrapancreatic gastrinomas, including ovarian and renal cases.
- Comparison of tumor location relative to the superior mesenteric artery.
Main Results:
- 85% of sporadic gastrinomas were located to the right of the superior mesenteric artery.
- All extrapancreatic gastrinomas in the study cohort were located to the right.
- Literature review identified 11 extrapancreatic gastrinomas (ovarian and renal), with 9 located on the right side.
Conclusions:
- Sporadic gastrinomas, both peripancreatic and extrapancreatic, show an unexpected right-sided preponderance.
- This consistent right-sided location suggests a shared embryological origin for gastrinomas.