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Subtype polymorphisms among HIV-1 protease variants confer altered flap conformations and flexibility

Jamie L Kear1, Mandy E Blackburn, Angelo M Veloro

  • 1Department of Chemistry, P.O. Box 117200, University of Florida, Gainesville, Florida 32611-7200, USA.

Journal of the American Chemical Society
|October 1, 2009
PubMed
Summary

Sequence variations in human immunodeficiency virus type 1 (HIV-1) protease affect flap conformations. These changes in flap dynamics influence the sampling of different conformational states, impacting viral maturation and potential drug targeting.

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