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Related Concept Videos

Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Pigmentation01:19

Pigmentation

The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...

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Related Experiment Video

Updated: Jun 20, 2026

Analysis of Lymph Node Volume by Ultra-High-Frequency Ultrasound Imaging in the Braf/Pten Genetically Engineered Mouse Model of Melanoma
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Analysis of Lymph Node Volume by Ultra-High-Frequency Ultrasound Imaging in the Braf/Pten Genetically Engineered Mouse Model of Melanoma

Published on: September 8, 2021

IMP-3 expression in melanocytic lesions.

Limin Yu1, Haodong Xu, Matthew J Wasco

  • 1Department of Pathology, Dermatopathology Division, University of Michigan, M3260, Medical Sciences 1, 1301 Catherine Street, Ann Arbor, MI 48109-0602, USA.

Journal of Cutaneous Pathology
|October 1, 2009
PubMed
Summary
This summary is machine-generated.

Insulin-like growth factor-II mRNA-binding protein 3 (IMP-3) is often positive in malignant melanomas and atypical Spitz tumors, but negative in benign nevi. This suggests IMP-3 may help diagnose melanoma and atypical Spitz tumors.

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Area of Science:

  • Oncology
  • Dermatopathology
  • Molecular Biology

Background:

  • Insulin-like growth factor-II mRNA-binding protein 3 (IMP-3) is implicated in various human cancers.
  • IMP-3 expression is known in melanomas but not fully characterized across all subtypes, including melanoma in situ and atypical Spitz tumors.

Purpose of the Study:

  • To investigate the expression patterns of IMP-3 in a spectrum of melanocytic lesions.
  • To determine the diagnostic utility of IMP-3 in differentiating malignant melanomas and atypical Spitz tumors from benign nevi.

Main Methods:

  • IMP-3 immunostaining was performed on 157 melanocytic lesions.
  • Statistical analysis was used to compare IMP-3 expression between different lesion types.

Main Results:

  • IMP-3 was largely negative in benign, dysplastic, and Spitz nevi.
  • Focal IMP-3 positivity was noted in melanoma in situ and superficial melanomas.
  • Strong IMP-3 staining was observed in deep melanomas, metastatic melanomas, and atypical Spitz tumors, with significant differences compared to benign lesions.

Conclusions:

  • IMP-3 expression is significantly associated with malignant melanomas (non-desmoplastic) and atypical Spitz tumors.
  • IMP-3 shows potential as a diagnostic marker for identifying malignant melanocytic lesions.
  • Further investigation into IMP-3's role in melanoma diagnosis is warranted.