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Successful treatment of a large hemangioma with propranolol

Waseem Mousa1, Kirsten Kues, Ellen Haas

  • 1Department of Dermatology, Venereology and Allergology, Georg August University Göttingen, Germany.

Journal Der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG
|October 1, 2009
PubMed

Insights

Propranolol effectively treats severe infantile hemangiomas, stopping growth and causing regression. This non-selective beta-blocker offers a well-tolerated option for infants when managed by pediatricians and dermatologists.

Area of Science:

  • Pediatric Oncology
  • Dermatology
  • Vascular Biology

Background:

  • Infantile hemangiomas are common pediatric vascular tumors, with unknown etiology.
  • Severe cases may present with rapid growth and ulceration, necessitating intervention.
  • Current management strategies for severe infantile hemangiomas are evolving.

Observation:

  • A premature infant with a large thoracic hemangioma experienced rapid growth and ulceration.
  • Systemic therapy was initiated due to the severity of the condition.
  • Treatment involved oral propranolol, a non-selective beta-blocker.

Findings:

  • Propranolol therapy halted hemangioma expansion within days.
  • Significant tumor regression was observed after 18 weeks of continuous treatment.
  • The treatment was well-tolerated by the infant.

Implications:

  • Propranolol shows promise as an effective and tolerable treatment for severe infantile hemangiomas.
  • Interdisciplinary cooperation between dermatology and pediatrics is crucial for optimal management.
  • Further research into propranolol's role in pediatric vascular tumors is warranted.

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