Related Experiment Video

Updated: Jun 20, 2026

Detection of Polyfunctional T Cells in Children Vaccinated with Japanese Encephalitis Vaccine via the Flow Cytometry Technique
09:37

Detection of Polyfunctional T Cells in Children Vaccinated with Japanese Encephalitis Vaccine via the Flow Cytometry Technique

Published on: September 23, 2022

Saffold cardiovirus in children with acute gastroenteritis, Beijing, China

Lili Ren1, Richard Gonzalez, Yan Xiao

  • 1State Key Laboratory for Molecular Virology and Genetic Engineering, Beijing, People's Republic of China.

Emerging Infectious Diseases
|October 1, 2009
PubMed

Insights

Saffold cardiovirus (SAFV) was detected in 3.2% of Chinese children with acute gastroenteritis. These SAFV-1 strains were found alongside other common viral pathogens, indicating potential co-infections.

Area of Science:

  • Virology
  • Pediatrics
  • Infectious Diseases

Background:

  • Saffold cardiovirus (SAFV) is an emerging viral pathogen.
  • Understanding its prevalence and clinical significance in pediatric populations is crucial.

Purpose of the Study:

  • To investigate the distribution, prevalence, and clinical relevance of Saffold cardiovirus in children with acute gastroenteritis in China.

Main Methods:

  • Retrospective study of pediatric patients diagnosed with acute gastroenteritis.
  • Detection of SAFV using molecular methods.
  • Sequence analysis of viral protein 1 genes.

Main Results:

  • SAFV was identified in 12 out of 373 (3.2%) children with acute gastroenteritis.
  • Phylogenetic analysis indicated the detected strains belong to the SAFV-1 sublineage.
  • SAFV co-infections were observed in samples positive for other enteric viruses.

Conclusions:

  • SAFV is present in pediatric gastroenteritis cases in China.
  • The findings highlight the SAFV-1 sublineage as a relevant genotype in this region.
  • Further research is needed to elucidate the clinical impact of SAFV, especially in co-infection settings.

Related Concept Videos

Bacterial Gastroenteritis01:18

Bacterial Gastroenteritis

Bacterial gastroenteritis, characterized by diarrhea, abdominal cramps, and vomiting, is often caused by ingestion of contaminated food or water and is frequently associated with pathogenic Escherichia coli strains. These microbes exploit two principal mechanisms to inflict disease.Shiga toxin–producing E. coli, also referred to as STEC—notably O157:H7—release Shiga toxins that target ribosomes, blocking protein synthesis. The B subunit of the toxin binds the host glycolipid receptor...
Poliomyelitis01:17

Poliomyelitis

Poliomyelitis is caused by poliovirus, a small, non-enveloped, positive-sense RNA virus of the Picornaviridae family and Enterovirus genus. Transmission occurs primarily via the fecal-oral route, often through ingestion of contaminated water or food. The virus initially replicates in the oropharynx and intestinal mucosa, particularly in lymphoid tissues such as the tonsils, Peyer’s patches, and regional lymph nodes. Primary viremia follows, allowing dissemination throughout the body.In most...
Respiratory Syncytial Virus Disease01:29

Respiratory Syncytial Virus Disease

Human respiratory syncytial virus (RSV) is a widespread pathogen that primarily targets infants and young children but also poses a serious health risk to elderly and immunocompromised individuals. Belonging to the Pneumoviridae family, RSV is a negative-sense, single-stranded RNA virus within the Pneumovirus genus. Its global health burden is significant, with millions of cases annually resulting in hospitalizations and mortality, particularly in resource-limited settings. Although most...
Cytomegalovirus Disease01:27

Cytomegalovirus Disease

Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...
Acute Pharyngitis01:30

Acute Pharyngitis

Introduction
Acute pharyngitis is the inflammation of the back of the throat (pharynx), commonly resulting in a sore throat. It is a frequently encountered condition that prompts individuals to seek medical advice.
Classification
Acute pharyngitis can be categorized based on its underlying cause:
Investigation of Disease Outbreaks01:23

Investigation of Disease Outbreaks

Multistate foodborne outbreaks pose significant public health risks and require meticulous investigation to identify sources and implement control measures. The Centers for Disease Control and Prevention (CDC) utilizes a dynamic seven-step process for these investigations, integrating data from laboratories, interviews, and environmental assessments to protect public health.Outbreak Detection: The detection of multistate outbreaks typically begins with PulseNet, the CDC's national laboratory...