Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mitogens and the Cell Cycle02:38

Mitogens and the Cell Cycle

Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
Mitogens and the Cell Cycle02:38

Mitogens and the Cell Cycle

Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
Animal Mitochondrial Genetics02:59

Animal Mitochondrial Genetics

Among all the organelles in an animal cell, only mitochondria have their own independent genomes. Animal mitochondrial DNA is a double-stranded, closed-circular molecule with around 20,000 base pairs. Mitochondrial DNA is unique in that one of its two strands, the heavy, or H, -strand is guanine rich, whereas the complementary strand is cytosine rich and called the light, or L, -strand. Compared to nuclear DNA, mitochondrial DNA has a very low percentage of non-coding regions and is marked by...
Anaphase Promoting Complex00:50

Anaphase Promoting Complex

The stepwise destruction of specific proteins is necessary for the progression and completion of the cell cycle. Such proteins are ubiquitinated by ubiquitin ligases and then subsequently destroyed by the proteasome. The SCF (Skp1/Cullin/F-box) and the anaphase-promoting complex (APC) are two important ubiquitin ligases involved in cell cycle progression. While SCF is active throughout the cell cycle, APC gets activated during metaphase to anaphase transition. Cdc20 or Cdh1 binds to APC and...
Comparing Mitochondrial, Chloroplast, and Prokaryotic Genomes02:16

Comparing Mitochondrial, Chloroplast, and Prokaryotic Genomes

The present-day mitochondrial and chloroplast genomes have retained some of the characteristics of their ancestral prokaryotes and also have acquired new attributes during their evolution within eukaryotic cells. Like prokaryotic genomes, mitochondrial and chloroplast genomes neither bind with histone-like proteins nor show complex packaging into chromosome-like structures, as observed in eukaryotes. Unlike mitotic cell divisions observed in eukaryotic cells, mitochondria and chloroplasts...
Genomics02:02

Genomics

Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Temporal genomics reveal rapid adaptation to pesticide exposure in Eastern honeybees.

National science review·2026
Same author

Paleogenomes reveal the evolutionary relationship between modern and cave lions.

Cell·2026
Same author

Publisher Correction: Continent-wide view of genomic diversity and divergence in the wolves of Asia.

Communications biology·2026
Same author

Functional gut microbiota dynamics of generalist and specialist bacteria in association with chicken growth.

ISME communications·2026
Same author

Draft assemblies for 177 bird species enhance genus-level coverage.

GigaScience·2026
Same author

The genomic basis of adaptive leaf variation in the Galápagos giant daisies.

Nature communications·2026
Same journal

miR-205-5p accelerates lung fibroblast senescence in IPF patients via mediation of mitochondrial dynamics.

Mitochondrion·2026
Same journal

A neuronal model of mtDNA disease reveals an ineffective reprogramming of the electron transfer chain during neuronal maturation.

Mitochondrion·2026
Same journal

ATPIF1, the rheostat in mitochondrial bioenergetics and dysfunction in diseases.

Mitochondrion·2026
Same journal

Spatholobi caulis and Epicatechin amplify erythropoiesis through mitochondrial translocation of AKT and enhanced oxidative phosphorylation.

Mitochondrion·2026
Same journal

DNM1L depletion leads to accelerated heteroplasmy shifting of m.10191C allele through ATG7-dependent pathways.

Mitochondrion·2026
Same journal

Energy beats: Daily and circadian rhythms in mitochondrial biology.

Mitochondrion·2026
See all related articles

Related Experiment Video

Updated: Jun 20, 2026

An In Vitro Approach to Study Mitochondrial Dysfunction: A Cybrid Model
06:05

An In Vitro Approach to Study Mitochondrial Dysfunction: A Cybrid Model

Published on: March 9, 2022

Ancient mitogenomics.

Simon Y W Ho1, M Thomas P Gilbert

  • 1Centre for Macroevolution and Macroecology, Research School of Biology, Australian National University, Canberra ACT 0200, Australia. simon.ho@anu.edu.au

Mitochondrion
|October 1, 2009
PubMed
Summary
This summary is machine-generated.

Ancient DNA research has advanced significantly, with rapid growth in ancient mitogenome sequencing. This review covers historical context, technical challenges, methods, and future directions in ancient mitogenomics.

More Related Videos

Primer Extension Capture: Targeted Sequence Retrieval from Heavily Degraded DNA Sources
15:28

Primer Extension Capture: Targeted Sequence Retrieval from Heavily Degraded DNA Sources

Published on: September 3, 2009

Using Cleavage Under Targets and Tagmentation (CUT&Tag) Assay in Mouse Myoblast Research
07:09

Using Cleavage Under Targets and Tagmentation (CUT&Tag) Assay in Mouse Myoblast Research

Published on: March 1, 2024

Related Experiment Videos

Last Updated: Jun 20, 2026

An In Vitro Approach to Study Mitochondrial Dysfunction: A Cybrid Model
06:05

An In Vitro Approach to Study Mitochondrial Dysfunction: A Cybrid Model

Published on: March 9, 2022

Primer Extension Capture: Targeted Sequence Retrieval from Heavily Degraded DNA Sources
15:28

Primer Extension Capture: Targeted Sequence Retrieval from Heavily Degraded DNA Sources

Published on: September 3, 2009

Using Cleavage Under Targets and Tagmentation (CUT&Tag) Assay in Mouse Myoblast Research
07:09

Using Cleavage Under Targets and Tagmentation (CUT&Tag) Assay in Mouse Myoblast Research

Published on: March 1, 2024

Area of Science:

  • Paleogenomics
  • Molecular Evolution
  • Bioinformatics

Background:

  • Mitochondrial DNA (mtDNA) is a primary target in ancient DNA (aDNA) research due to its high copy number and variability.
  • The first complete ancient mitogenome sequence was obtained in 2001, marking a significant milestone.

Purpose of the Study:

  • To provide a historical overview of ancient mitogenomics.
  • To discuss technical challenges and methodological advancements in the field.
  • To summarize genetic and phylogenetic studies utilizing ancient mitogenomes and assess future prospects.

Main Methods:

  • Review of historical data and scientific literature.
  • Cataloguing of sequencing methods and source materials for ancient mitogenomes.
  • Analysis of genetic and phylogenetic studies.

Main Results:

  • Significant increase in ancient mitogenome sequence data due to high-throughput sequencing.
  • Diverse range of methods and materials employed in ancient mitogenomics.
  • Established utility of ancient mitogenomes in genetic and phylogenetic research.

Conclusions:

  • Ancient mitogenomics has evolved rapidly, overcoming initial technical hurdles.
  • Continued methodological improvements promise further expansion of ancient DNA research.
  • The field holds substantial potential for future discoveries in evolutionary biology and human history.