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Related Experiment Video

Updated: Jun 19, 2026

Microfluidic Platform with Multiplexed Electronic Detection for Spatial Tracking of Particles
11:54

Microfluidic Platform with Multiplexed Electronic Detection for Spatial Tracking of Particles

Published on: March 13, 2017

A multiplexed optofluidic biomolecular sensor for low mass detection.

Sudeep Mandal1, Julie M Goddard, David Erickson

  • 1School of Applied and Engineering Physics, Cornell University, Ithaca, NY 14853, USA.

Lab on a Chip
|October 1, 2009
PubMed
Summary

This study introduces a novel optofluidic biosensor with enhanced light-matter interaction for highly sensitive biomolecular detection. The new platform achieves a significantly lower limit of detection and improved sensitivity for multiplexed assays.

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Area of Science:

  • Biophotonics
  • Nanotechnology
  • Biosensing

Background:

  • Optical biosensors offer label-free, in situ biomolecular detection in aqueous environments.
  • High quality-factor resonators enhance sensitivity but suffer from limited light-matter interaction.
  • Confined optical fields reduce device sensitivity by limiting overlap with bound analytes.

Purpose of the Study:

  • To develop a novel optofluidic biosensor platform with enhanced light-matter interaction.
  • To improve the sensitivity and limit of detection for biomolecular sensing.
  • To demonstrate multiplexed detection capabilities for specific biomarkers.

Main Methods:

  • Integration of a one-dimensional photonic crystal resonator array into an optofluidic platform.
  • Utilizing planar photonic crystals to localize optical fields to sub-wavelength volumes.

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Last Updated: Jun 19, 2026

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  • Employing a sandwich assay for the detection of interleukins 4, 6, and 8.

    • Main Results:

    • Achieved a limit of detection on the order of 63 attograms (ag) of total bound mass.
    • Demonstrated a device sensitivity an order of magnitude better than similar existing devices.
    • Successfully performed individual and concurrent detection of interleukins 4, 6, and 8.

    Conclusions:

    • The novel optofluidic biosensor platform significantly enhances light-matter interaction for superior biomolecular sensing.
    • The platform offers ultra-low limits of detection and high sensitivity, suitable for detecting minute amounts of biomolecules.
    • The demonstrated multiplexing capability enables simultaneous detection of multiple biomarkers, advancing diagnostic applications.