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Updated: Jun 19, 2026

Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
Published on: May 28, 2014
Unusual metal coordination chemistry from an amino-amide derivative of 4-nitrophenol, a surprising ligand
John McGinley1, Vickie McKee, Hans Toftlund
1Chemistry Department, National University of Ireland Maynooth, Maynooth, Co. Kildare, Ireland. john.mcginley@nuim.ie
Abstract:
The simple ligand N-(2-aminoethyl)-2-hydroxy-5-nitrobenzamide () exhibits several coordination modes depending on the reaction conditions, acting as a zwitterion on its own or being ionic in the presence of acid and depending on the concentration of metal present in a reaction, it can coordinate to the metal in either a 1:1 or a 1:2 metal:ligand mode. Furthermore, the role of solvent plays an important role in these complexation reactions with both four and six coordinate copper complexes being obtained using water as solvent but only six coordinate copper complexes obtained using acetonitrile as solvent.
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