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Updated: Jun 19, 2026

In Vivo Infection with Leishmania amazonensis to Evaluate Parasite Virulence in Mice
Published on: February 20, 2020
Bioactivity of flavonoids isolated from Lychnophora markgravii against Leishmania amazonensis amastigotes
Marcos José Salvador1, Fabiana Terezinha Sartori, Ana Claudia B C Sacilotto
1Curso de Farmácia, Instituto de Biologia, Departamento de Biologia Vegetal, Universidade Estadual de Campinas (UNICAMP), Caixa Postal 6109, CEP 13083-970, Campinas (SP), Brazil. mjsalvador@bol.com.br
Abstract:
The bioactivity of the flavonoids pinostrobin (1), pinocembrin (2), tectochrysin (3), galangin 3-methyl ether (4), and tiliroside (5) isolated from Lychnophora markgravii aerial parts was investigated in vitro against amastigote stages of Leishmania amazonensis. The compounds were isolated by several chromatographic techniques and their chemical structures were established by ESI-MS and NMR spectroscopic data. The flavonoids 1 and 3 were the most active compounds; they markedly reduced the viability of Leishmania amastigotes.
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