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[State of cerebral circulation in patients with essential arterial hypertension]

F I Todua, D G Gachechiladze, M V Razmadze

    Angiologiia I Sosudistaia Khirurgiia = Angiology and Vascular Surgery
    |October 2, 2009
    PubMed

    Insights

    Hypertension and atherosclerosis thicken carotid arteries, reducing blood flow. This study in 159 patients shows reduced flow and increased resistance in cerebral arteries, especially with combined conditions and longer disease duration.

    Area of Science:

    • Vascular Medicine
    • Cardiology
    • Neurology

    Background:

    • Arterial hypertension (AH) affects blood flow and cerebral hemodynamics.
    • Carotid artery (CA) pathologies can influence intracranial circulation.
    • Understanding these impacts is crucial for managing hypertensive patients.

    Purpose of the Study:

    • To evaluate blood flow rates in extracranial arteries.
    • To assess intracranial hemodynamics in patients with isolated AH and CA pathologies.
    • To correlate these findings with hypertension severity and duration.

    Main Methods:

    • Analysis of 159 patients (mild, moderate, severe AH).
    • Measurement of intima-medial thickness of the common carotid artery.
    • Assessment of volumetric blood flow rate in extracranial vessels.
    • Evaluation of flow-rate indices and peripheral resistance in the Circle of Willis arteries.

    Main Results:

    • Intima-medial thickening observed in isolated AH and CA atherosclerosis, more pronounced in combined cases.
    • Decreased volumetric blood flow rate in extracranial vessels and total flow rate in AH patients, especially with atherosclerosis.
    • Altered flow-rate indices and increased peripheral resistance in Circle of Willis arteries, particularly in prolonged AH cases.

    Conclusions:

    • Structural changes in extracranial arteries and hypertensive microangiopathy contribute to reduced blood flow and increased vascular resistance in hypertensive patients.
    • Combined AH and atherosclerosis significantly impacts vascular hemodynamics.
    • Findings highlight the importance of assessing extracranial and intracranial circulation in hypertensive individuals.

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