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Related Experiment Video

Updated: Jun 19, 2026

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay

Published on: February 9, 2021

Comparative reprotoxicity of three oximes.

George M Rusch¹, Ann Tveit, Ine D H Waalkens-Berendsen

¹Honeywell International, Morristown, New Jersey 07962-1139, USA. george.rusch@honeywell.com

Drug and Chemical Toxicology

|October 2, 2009

Summary

Reproductive toxicity studies on three oximes showed parental toxicity including anemia and spleen changes. No significant reproductive or F1 generation effects were observed, except for increased stillbirths with Aldecarb Oxime (ADO).

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Solid-phase Synthesis of [4.4] Spirocyclic Oximes

Solid-phase Synthesis of [4.4] Spirocyclic Oximes

Published on: February 6, 2019

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Last Updated: Jun 19, 2026

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay

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Published on: February 9, 2021

Solid-phase Synthesis of [4.4] Spirocyclic Oximes

Solid-phase Synthesis of [4.4] Spirocyclic Oximes

Published on: February 6, 2019

Area of Science:

Toxicology
Reproductive Toxicology
Chemical Safety Assessment

Background:

Oximes are industrial chemicals with potential toxicological impacts.
Understanding the reproductive and developmental effects of oximes is crucial for risk assessment.

Purpose of the Study:

To evaluate the one-generation reproductive toxicity of acetaldehyde oxime (AAO), aldecarb oxime (ADO), and methyl isobutyl ketoxime (MIBKO).
To determine No-Observed-Adverse-Effect Levels (NOAELs) for parental and offspring toxicity.

Main Methods:

Studies followed the OECD 415 guideline for One-Generation Reproduction Toxicity.
Rats were exposed to oximes prior to and during mating, gestation, and lactation.
F1 generation exposure was included for MIBKO until sexual maturation.

Main Results:

Parental toxicity (F0) included hemolytic anemia, extramedullary hematopoiesis, and hemosiderosis of the spleen for all three oximes.
Aldecarb oxime (ADO) high-dose group showed an increased number of stillbirths.
NOAELs varied: AAO (F0 <5 mg/kg/day, F1/Repro 50 mg/kg/day), ADO (F0 <5 mg/kg/day, F1/Repro 25 mg/kg/day), MIBKO (F0 30 mg/kg/day, F1/Repro 100 mg/kg/day).

Conclusions:

Oximes can induce parental toxicity, primarily hematological and splenic effects.
Reproductive toxicity was minimal, with ADO showing a dose-dependent increase in stillbirths.
Established NOAELs provide critical data for risk assessment of these oximes.