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Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation
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Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation

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A bioinformatics approach to ascertaining the rarity of HLA alleles

D Middleton1, F Gonzalez, M Fernandez-Vina

  • 1Transplant Immunology, Royal Liverpool University Hospital and School of Infection and Host Defence, University of Liverpool, Liverpool, UK. derek.middleton@rlbuht.nhs.uk

Tissue Antigens
|October 2, 2009
PubMed

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Genome-wide Association Studies-GWAS01:11

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Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...