Related Experiment Video
Updated: Jun 19, 2026

A Murine Model of a Burn Wound Reconstructed with an Allogeneic Skin Graft
Published on: August 8, 2020
Closure of the excised burn wound: temporary skin substitutes
1Department of Surgery, University of Utah Health Center, Salt Lake City, 84132, USA. jeffrey.saffle@hsc.utah.edu
Abstract:
Prompt excision of major burn wounds has been repeatedly shown to improve survival, speed closure, and reduce infection. Immediate coverage with autograft skin is the preferred method of definitive closure of these wounds. However, when harvesting of donor skin is unavailable, or wounds are not ready for autografting, temporary closure with a variety of products can help reduce evaporative loss, prevent infection, and ameliorate pain and metabolic stress. Fresh cadaver allograft is the gold standard for such closure, but other products, including frozen cadaver skin, xenografts, and several synthetic products, are also available. This article reviews the physiology, and types of products, and their uses.
Related Concept Videos
Burn Injuries
The damage results in the death of skin cells, which can lead to a massive loss of fluid. Dehydration, electrolyte imbalance, and renal and circulatory failure follow, which can be fatal. Burn patients are treated with intravenous fluids to offset...
Clinical Applications of Epidermal Stem Cells
Healing II: Complications
Phases of Wound Repair
Formation of Blood Clot
In case of deep injuries, trauma to blood vessels results in blood loss. In the meantime, phospholipids released from the ruptured endothelial cellular membrane are converted into arachidonic...
Tracheostomy Decannulation
Description of the Procedure
Decannulation refers to the permanent removal of the tracheostomy tube, signaling the resolution of the condition that initially necessitated the tracheostomy. The process requires a well-coordinated interplay between...

