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Updated: Jun 19, 2026
08:57
Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models
Published on: May 17, 2024
Solitary fibrous tumor
Cem Yilmaz1, Serdar Kabatas, Ozlem Isiksacan Ozen
1Department of Neurosurgery, Baskent University, Fevzi Cakmak Caddesi, 10. sokak No. 45 C Blok 1. kat 06490 Bahcelievler, Ankara, Turkey. cemy@baskent-ank.edu.tr
Summary
Solitary fibrous tumors (SFT) are rare intracranial neoplasms. Immunohistochemistry is crucial for distinguishing SFT from other spindle cell tumors, especially hemangiopericytomas.
Area of Science:
- Neuropathology
- Neurosurgery
- Oncology
Background:
- Intracranial solitary fibrous tumors (SFT) are rare, dural-based, CD34-positive mesenchymal neoplasms.
- Fewer than 100 intracranial and spinal SFTs have been reported since their initial description in 1996.
- SFTs can mimic other spindle cell tumors radiologically and histopathologically.
Purpose of the Study:
- To present four cases of intracranial solitary fibrous tumors.
- To highlight the diagnostic challenges and the importance of immunohistochemistry in SFT identification.
- To re-evaluate previously diagnosed hemangiopericytomas for potential SFT misdiagnosis.
Main Methods:
- Review of pathological files for intracranial SFT cases.
- Histopathological and ultrastructural examination of tumor samples.
- Immunohistochemical analysis to confirm SFT diagnosis.
Main Results:
- Four patients with intracranial SFT were identified.
- Two cases were located in the cerebellopontine angle and parasagittal regions.
- Two additional cases, initially diagnosed as hemangiopericytoma, were reclassified as SFT upon immunohistochemical re-examination.
Conclusions:
- Intracranial SFTs require careful diagnostic evaluation.
- Immunohistochemistry is essential for accurate differentiation of SFTs from similar neoplasms.
- Re-evaluation of prior diagnoses may reveal misclassified SFT cases.
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