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Related Concept Videos

Radiological Investigation I: X-ray and CT01:30

Radiological Investigation I: X-ray and CT

Radiological investigations, including X-rays and computed tomography (CT) scans, are critical for diagnosing and evaluating various medical conditions. These imaging techniques provide valuable insights into the body's internal structures, aiding in the detection of abnormalities, assessment of disease progression, and development of treatment strategies. This article delves into two primary radiological investigations, chest X-rays and CT scans, outlining their purpose, procedures, and the...
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Cardiac computed tomography (CT) scanning is an advanced cardiac imaging technique that utilizes CT technology, with or without intravenous (IV) contrast, to produce accurate cross-sectional virtual slices of specific areas of the heart, coronary circulation, and major blood vessels such as the aorta, pulmonary veins, and arteries. The computer processes these slices to generate three-dimensional images. Multidetector CT (MDCT) is a rapid form of CT scanning that captures multiple slices...

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Related Experiment Video

Updated: Jun 19, 2026

Whole-body PET/MRI of Pediatric Patients: The Details That Matter
10:02

Whole-body PET/MRI of Pediatric Patients: The Details That Matter

Published on: December 19, 2017

Weight-based, low-dose pediatric whole-body PET/CT protocols.

Adam M Alessio1, Paul E Kinahan, Vivek Manchanda

  • 1Department of Radiology, University of Washington, Old Fisheries Center, Seattle, Washington 98195-7987, USA. aalessio@u.washington.edu

Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
|October 2, 2009
PubMed
Summary

New low-dose PET/CT protocols for pediatric patients customize imaging based on weight, reducing radiation exposure and cancer risk while maintaining diagnostic quality. These protocols aim to minimize radiation dose for children undergoing PET/CT scans.

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Area of Science:

  • Medical Imaging
  • Nuclear Medicine
  • Pediatric Radiology

Background:

  • Standard adult PET/CT protocols pose risks for pediatric patients due to higher sensitivity to radiation.
  • Minimizing radiation dose in pediatric imaging is crucial while preserving diagnostic accuracy.

Purpose of the Study:

  • To develop and evaluate customized, low-dose PET/CT acquisition protocols for pediatric patients.
  • To estimate the dosimetry and associated cancer risks of these optimized protocols.

Main Methods:

  • Developed weight-based protocols for whole-body (18)F-FDG PET and CT imaging.
  • Utilized Broselow-Luten scale for patient categorization.
  • Calculated dosimetry and lifetime attributable risk (LAR) of cancer using accepted patient models.

Main Results:

  • Proposed protocols yield effective doses from 8.0 to 13.5 mSv, depending on patient weight.
  • Radiation dose is reduced by 20%-50% compared to standard protocols.
  • Estimated additional LAR of cancer incidence is approximately 3 in 1,000 for females and 2 in 1,000 for males.

Conclusions:

  • Developed low-dose PET/CT protocols tailored for 11 pediatric weight categories.
  • Protocols provide initial parameters for pediatric PET/CT, balancing dose reduction and image quality.
  • Multi-category approach allows for ongoing refinement of dose-reduction strategies.