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Updated: Jun 19, 2026

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Published on: September 5, 2015
Inhibition of presynaptic release-facilitatory kainate autoreceptors by extracellular cyclic GMP
Chiara Cervetto1, Guido Maura, Manuela Marcoli
1Department of Experimental Medicine, Pharmacology and Toxicology Section, University of Genoa, Genoa, Italy.
Abstract:
We found that both alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) and kainate autoreceptors were present on the glutamate-releasing terminals of cerebellar parallel/climbing fibers and that they functioned as facilitatory autoreceptors. Extracellular cGMP inhibited the neurotransmitter release evoked by presynaptic kainate receptor activation; the inhibitory effect of extracellular cGMP was selective for the kainate autoreceptor-mediated response and did not affect the AMPA autoreceptor-mediated response. Endogenously synthesized cGMP might be the physiological source for the extracellular cGMP modulating the response to kainate autoreceptor activation.
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