Prognostic and therapeutic potential of nuclear receptors in head and neck squamous cell carcinomas

Area of Science:

• Oncology
• Molecular Biology
• Genetics

Background:

• Head and neck squamous cell carcinomas (HNSCC) are prevalent globally, marked by aggressive local growth, frequent recurrences, metastasis, and secondary primary tumors.
• Current therapeutic strategies and surgical interventions have not significantly improved overall survival rates for HNSCC over recent decades.
• The development of novel treatment strategies for HNSCC is critically needed.

Purpose of the Study:

• To review the role of nuclear receptors in the development and progression of head and neck cancer.
• To summarize the mode of action, prognostic, and therapeutic relevance of nuclear receptors in HNSCC.
• To consolidate findings from preclinical and clinical studies targeting nuclear receptors in HNSCC.

Main Methods:

• Literature review of scientific publications on nuclear receptors and head and neck cancer.
• Analysis of studies investigating the function and therapeutic potential of nuclear receptors in HNSCC.
• Synthesis of data from preclinical models and clinical trials involving nuclear receptor-targeted therapies.

Main Results:

• Nuclear receptors, a large superfamily of transcription factors, are implicated in various physiological and pathophysiological processes, including carcinogenesis.
• Several nuclear receptors have been associated with the development and progression of head and neck cancer.
• Emerging evidence suggests nuclear receptors represent promising targets for novel HNSCC therapies.

Conclusions:

• Nuclear receptors play a significant role in HNSCC, influencing tumor aggressiveness and treatment response.
• Targeting nuclear receptors offers a potential avenue for developing innovative therapeutic strategies for head and neck cancer.
• Further research and clinical investigation into nuclear receptor-targeted therapies are warranted for HNSCC management.