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Related Experiment Video

Updated: Jun 19, 2026

Using SecM Arrest Sequence as a Tool to Isolate Ribosome Bound Polypeptides

Using SecM Arrest Sequence as a Tool to Isolate Ribosome Bound Polypeptides

Published on: June 19, 2012

The arrestin fold: variations on a theme.

Laurence Aubry¹, Dorian Guetta, Gérard Klein

¹CNRS, UMR 5092, 17 rue des Martyrs, Grenoble, 38054, France.

Current Genomics

|October 2, 2009

Summary

This summary is machine-generated.

This study analyzes the arrestin protein clan, revealing structural similarities between beta-arrestins and VPS26. It explores the diverse functions of arrestin-related proteins (ADCs) across species.

Keywords:

Arrestins GPCR Vps26 endocytosis.retromer trafficking

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Last Updated: Jun 19, 2026

Using SecM Arrest Sequence as a Tool to Isolate Ribosome Bound Polypeptides

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Parallel Interrogation of β-Arrestin2 Recruitment for Ligand Screening on a GPCR-Wide Scale using PRESTO-Tango Assay

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Published on: June 28, 2019

Area of Science:

Cell Biology
Structural Biology
Molecular Biology

Background:

Endocytosis of activated receptors regulates downstream signaling.
Beta-arrestins scaffold proteins for receptor endocytosis.
VPS26, a retromer subunit, shares an arrestin fold.

Purpose of the Study:

To analyze the arrestin protein clan.
To review structures and functions of arrestin-related proteins (ADCs).
To compare arrestin functions in mammals and model organisms.

Main Methods:

Structural analysis of VPS26.
Bioinformatic analysis of arrestin-related proteins (ADCs).
Literature review of arrestin clan functions.

Main Results:

VPS26 exhibits an unexpected arrestin fold.
Mammalian cells contain numerous ADCs with poorly understood roles.
Arrestin clan comprises genuine arrestins, VPS26, and ADCs.

Conclusions:

The arrestin clan is structurally and functionally diverse.
Further research is needed to elucidate ADC functions.
Comparative analysis across species aids understanding of arrestin evolution.