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Updated: Jun 19, 2026
A Novel Method to Determine the Longitudinal Antibacterial Activity of Drug-Eluting Materials
Published on: March 3, 2023
Prophylactic use of antibiotic-loaded bone cement in primary total knee replacement
Pietro Randelli1, Francesco R Evola, Paolo Cabitza
1Dipartimento di Scienze Medico-Chirurgiche, Università degli Studi di Milano, Policlinico San Donato IRCCS, Via Morandi 30, San Donato Milanese, 20097, Milan, Italy. pietro.randelli@tin.it
Abstract:
Despite significant advances in intraoperative antimicrobial procedures, deep infection remains the most devastating complication following total joint arthroplasty. Clinical studies' results and safety profile of antibiotic-loaded bone cement are discussed in this review. Antibiotic bone cement prophylaxis is a safe and effective strategy in reducing the risk of deep infection following primary total joint arthroplasty.