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Related Concept Videos

Autoimmune Disorders01:29

Autoimmune Disorders

Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
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Related Experiment Video

Updated: Jun 19, 2026

A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology
05:51

A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology

Published on: May 6, 2014

Autoimmunity, infectious immunity, and atherosclerosis.

Eiji Matsuura1, Kazuko Kobayashi, Yukana Matsunami

  • 1Department of Cell Chemistry, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Kita-ku, Okayama, Japan. eijimatu@md.okayama-u.ac.jp

Journal of Clinical Immunology
|October 2, 2009
PubMed
Summary

Immune responses to infections and autoimmunity can promote atherosclerosis. While cellular immunity may drive disease, antibody production might be protective against cardiovascular disease development.

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Area of Science:

  • Immunology
  • Cardiovascular Research
  • Autoimmunity

Background:

  • Vascular inflammation is a key factor in systemic autoimmune diseases.
  • Oxidized low-density lipoprotein (oxLDL) and its complexes with beta2-glycoprotein I (beta2GPI) are implicated in atherosclerosis.
  • These complexes act as proatherogenic autoantigens.

Purpose of the Study:

  • To investigate the role of IgG anti-beta2GPI antibodies in macrophage uptake of oxLDL/beta2GPI complexes.
  • To explore how IgG immune complexes influence scavenger and Fcgamma receptor expression.
  • To examine the link between persistent infections, immune responses, and atherosclerosis.

Main Methods:

  • In vitro studies of macrophage uptake of oxLDL/beta2GPI complexes.
  • Analysis of scavenger and Fcgamma receptor expression.
  • Review of recent advancements in autoimmunity and infectious immunity related to atherosclerosis.

Main Results:

  • Macrophage uptake of oxLDL/beta2GPI complexes increased with IgG anti-beta2GPI antibodies.
  • IgG immune complexes upregulated scavenger and Fcgamma receptors, activating beta2GPI-specific T cells.
  • Cellular immunity (Th1) against Helicobacter pylori heat shock protein 60 (Hp-HSP60) may cause cardiovascular disease via molecular mimicry.

Conclusions:

  • Infectious cellular immune responses can be proatherogenic.
  • Humoral immune responses (antibody production) may offer protection against atherosclerosis.
  • Autoimmunity and specific infectious triggers contribute to the development of atherosclerotic disease.