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Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)
12:18

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)

Published on: February 9, 2011

Microscopic polyangiitis triggered by recurrent methicillin-resistant Staphylococcus aureus bacteremia

Rahil Kasmani1, Kelechi Okoli, Kalpana Naraharisetty

  • 1Department of Internal Medicine, St Vincent Mercy Medical Center, 2213, Cherry Street, Toledo, OH 43608, USA. rahilkasmani@hotmail.com

International Urology and Nephrology
|October 2, 2009
PubMed

Insights

Staphylococcus aureus bacteremia may trigger anti-neutrophil cytoplasmic antibody-associated vasculitis. This case highlights a potential link between recurrent Staph infections and ANCA-positive small-vessel vasculitis, particularly.

Area of Science:

  • Nephrology
  • Rheumatology
  • Infectious Diseases

Background:

  • The association between microbial agents and anti-neutrophil cytoplasmic antibody-positive (ANCA) vasculitides is often speculative.
  • Staphylococcus aureus is implicated in Wegener's granulomatosis, but its role in other ANCA-associated vasculitides is less understood.

Observation:

  • A patient presented with non-granulomatous, necrotizing small-vessel vasculitis.
  • The patient tested positive for perinuclear anti-neutrophil cytoplasmic antibodies (p-ANCA) and anti-myeloperoxidase (MPO) antibodies.
  • This condition developed subsequent to recurrent episodes of methicillin-resistant Staphylococcus aureus (MRSA) bacteremia.

Findings:

  • This case suggests a potential causal link between recurrent MRSA bacteremia and the development of p-ANCA/anti-MPO-positive vasculitis.
  • The vasculitis observed was distinct from the typical granulomatous presentation seen in Wegener's granulomatosis.

Implications:

  • This case broadens the understanding of potential triggers for ANCA-associated vasculitis.
  • It underscores the importance of considering and managing Staphylococcal infections in patients with unexplained vasculitis.
  • Further research is warranted to explore the mechanisms connecting S. aureus infections to ANCA vasculitis development.

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