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Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)

Published on: February 9, 2011

Microscopic polyangiitis triggered by recurrent methicillin-resistant Staphylococcus aureus bacteremia.

Rahil Kasmani¹, Kelechi Okoli, Kalpana Naraharisetty

¹Department of Internal Medicine, St Vincent Mercy Medical Center, 2213, Cherry Street, Toledo, OH 43608, USA. rahilkasmani@hotmail.com

International Urology and Nephrology

|October 2, 2009

Summary

Staphylococcus aureus bacteremia may trigger anti-neutrophil cytoplasmic antibody-associated vasculitis. This case highlights a potential link between recurrent Staph infections and ANCA-positive small-vessel vasculitis, particularly.

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Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)

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Published on: February 9, 2011

A Mouse Model to Assess Innate Immune Response to Staphylococcus aureus Infection

A Mouse Model to Assess Innate Immune Response to Staphylococcus aureus Infection

Published on: February 28, 2019

Area of Science:

Nephrology
Rheumatology
Infectious Diseases

Background:

The association between microbial agents and anti-neutrophil cytoplasmic antibody-positive (ANCA) vasculitides is often speculative.
Staphylococcus aureus is implicated in Wegener's granulomatosis, but its role in other ANCA-associated vasculitides is less understood.

Observation:

A patient presented with non-granulomatous, necrotizing small-vessel vasculitis.
The patient tested positive for perinuclear anti-neutrophil cytoplasmic antibodies (p-ANCA) and anti-myeloperoxidase (MPO) antibodies.
This condition developed subsequent to recurrent episodes of methicillin-resistant Staphylococcus aureus (MRSA) bacteremia.

Findings:

This case suggests a potential causal link between recurrent MRSA bacteremia and the development of p-ANCA/anti-MPO-positive vasculitis.
The vasculitis observed was distinct from the typical granulomatous presentation seen in Wegener's granulomatosis.

Implications:

This case broadens the understanding of potential triggers for ANCA-associated vasculitis.
It underscores the importance of considering and managing Staphylococcal infections in patients with unexplained vasculitis.
Further research is warranted to explore the mechanisms connecting S. aureus infections to ANCA vasculitis development.