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Related Concept Videos

Proteomics01:33

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term proteomics...
Ribosome Profiling02:24

Ribosome Profiling

Ribosome profiling or ribo-sequencing is a deep sequencing technique that produces a snapshot of active translation in a cell. It selectively sequences the mRNAs protected by ribosomes to get an insight into a cell’s translation landscape at any given point in time.
Applications of ribosome profiling
Ribosome profiling has many applications, including in vivo monitoring of translation inside a particular organ or tissue type and quantifying new protein synthesis levels.
The technique helps...
Protein Networks02:26

Protein Networks

An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
Conservation of Protein Domains Over Different Proteins02:26

Conservation of Protein Domains Over Different Proteins

Protein domains are small structurally independent units that are part of a single amino acid chain.  Although these domains are often structurally independent, they may rely on synergistic effects to perform their functions as part of a larger protein. Protein domains may be conserved within the same organism, as well as across different organisms.
A limited set of protein domains often duplicate and recombine during evolution. These domains can be organized in different combinations to form...
Conservation of Protein Domains02:26

Conservation of Protein Domains

Protein domains are small structurally independent units that are part of a single amino acid chain.  Although these domains are often structurally independent, they may rely on synergistic effects to perform their functions as part of a larger protein. Protein domains may be conserved within the same organism, as well as across different organisms.
A limited set of protein domains often duplicate and recombine during evolution. These domains can be organized in different combinations to form...

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TMT Sample Preparation for Proteomics Facility Submission and Subsequent Data Analysis
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TMT Sample Preparation for Proteomics Facility Submission and Subsequent Data Analysis

Published on: June 8, 2020

Proteomics data repositories.

Michael Riffle1, Jimmy K Eng

  • 1Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.

Proteomics
|October 2, 2009
PubMed
Summary
This summary is machine-generated.

This review highlights freely accessible proteomics data repositories for sharing mass spectrometry (MS) experimental data and results. It focuses on resources beneficial for yeast researchers, detailing their purpose and features.

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Area of Science:

  • Proteomics
  • Bioinformatics
  • Data Science

Background:

  • The field of proteomics is rapidly expanding, generating vast amounts of experimental data.
  • Effective dissemination of proteomic data is crucial for biological research.
  • Centralized data repositories are essential for managing and sharing proteomic datasets.

Purpose of the Study:

  • To review freely available, centralized proteomics data repositories.
  • To provide a snapshot of current resources for MS-based proteomics data.
  • To emphasize resources particularly relevant for yeast researchers.

Main Methods:

  • Literature review and resource curation.
  • Focus on repositories storing or disseminating experimental MS data and results.
  • Analysis of repository purpose, features, and user functionality.

Main Results:

  • Identification and description of key proteomics data repositories.
  • Categorization of resources based on their utility and accessibility.
  • Highlighting of resources valuable for the yeast research community.

Conclusions:

  • Centralized data repositories are vital for the advancement of proteomics research.
  • Accessible data sharing platforms enhance reproducibility and collaboration.
  • This review serves as a guide to valuable resources for proteomic data management and discovery.