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Updated: Jun 19, 2026

Isolation of Perivascular Multipotent Precursor Cell Populations from Human Cardiac Tissue

Isolation of Perivascular Multipotent Precursor Cell Populations from Human Cardiac Tissue

Published on: October 8, 2016

Perivascular multipotent progenitor cells in human organs.

Mihaela Crisan¹, Chien-Wen Chen, Mirko Corselli

¹Stem Cell Research Center, Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA.

Annals of the New York Academy of Sciences

|October 3, 2009

Summary

Human pericytes from various organs possess progenitor cell capabilities. These vascular cells express mesenchymal stem cell markers and can differentiate into bone, cartilage, and fat cells.

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Published on: October 8, 2016

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Differentiation Capacity of Human Aortic Perivascular Adipose Progenitor Cells

Differentiation Capacity of Human Aortic Perivascular Adipose Progenitor Cells

Published on: March 5, 2019

Area of Science:

Cell Biology
Regenerative Medicine
Vascular Biology

Background:

Mesenchymal stem cells (MSCs) are crucial for tissue repair and regeneration.
The precise origin and in vivo identification of MSCs remain challenging.
Pericytes are perivascular cells integral to microvessel stability.

Purpose of the Study:

To identify and characterize progenitor cells within human vascular structures.
To investigate the potential of pericytes as a source of MSCs.
To explore the differentiation capacity of these identified cells.

Main Methods:

Immunophenotypic analysis of pericytes using specific cell surface markers (CD146, NG2, PDGF-Rbeta, CD44, CD73, CD90, CD105).
Assessment of myogenic potential in vitro and in vivo.
Long-term culture of purified pericytes.
Clonal analysis of osteogenic, chondrogenic, and adipogenic differentiation potential.

Main Results:

Vascular pericytes from multiple human organs were identified by specific cell surface markers.
Purified pericytes demonstrated myogenic capacity and sustained long-term culture.
These pericytes expressed MSC markers and exhibited multipotent differentiation potential (osteogenic, chondrogenic, adipogenic) at the clonal level.

Conclusions:

Human pericytes represent a readily accessible source of progenitor cells with MSC-like properties.
Capillary and microvessel walls harbor a reserve of progenitor cells that may be the origin of MSCs.
This finding offers new insights into the cellular origins of MSCs and their potential therapeutic applications.