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Related Concept Videos

EPS and iPS Cells in Disease Research01:21

EPS and iPS Cells in Disease Research

Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...
Induced Pluripotent Stem Cells01:06

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic cells are...
Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore called induced pluripotent stem...
Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore called induced pluripotent stem...
iPS Cell Differentiation01:22

iPS Cell Differentiation

The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
Stem Cell Culture01:17

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...

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Related Experiment Video

Updated: Jun 19, 2026

Modeling Osteosarcoma Using Li-Fraumeni Syndrome Patient-derived Induced Pluripotent Stem Cells
08:52

Modeling Osteosarcoma Using Li-Fraumeni Syndrome Patient-derived Induced Pluripotent Stem Cells

Published on: June 13, 2018

Disease models from pluripotent stem cells.

Claudia Lengerke1, George Q Daley

  • 1Division of Hematology and Oncology, University of Tuebingen Medical Center II, Tuebingen, Germany. claudia.lengerke@med.uni-tuebingen.de

Annals of the New York Academy of Sciences
|October 3, 2009
PubMed
Summary
This summary is machine-generated.

Embryonic stem cells offer a human model for studying disease development. These cells enable research into disease initiation and the creation of personalized cellular therapies.

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Area of Science:

  • Developmental biology
  • Stem cell research
  • Disease modeling

Background:

  • Murine models of disease often fail to accurately reflect human pathophysiology.
  • Embryonic stem (ES) cells differentiated in vitro mimic early human embryogenesis and somatic tissue development.
  • ES cells provide a valuable platform for studying human development.

Purpose of the Study:

  • To explore the utility of genetically modified ES cells for studying disease initiation and progression during embryonic development.
  • To investigate the potential of ES cells and induced pluripotent stem (iPS) cells for understanding disease pathogenesis.
  • To highlight the application of these cellular models in developing customized cellular therapies.

Main Methods:

  • Utilizing genetically modified ES cells through lentiviral gene transduction.
  • Deriving ES cells from embryos with genetic diseases.
  • Employing somatic cell reprogramming to generate iPS cells from patients.

Main Results:

  • Genetically modified ES cells allow detailed study of disease initiation and progression in embryonic development.
  • ES cells and iPS cells offer insights into the gradual pathogenesis of various disorders.
  • In vitro gene correction in autologous cells demonstrates potential for customized therapies.

Conclusions:

  • Embryonic stem cells and iPS cells are powerful tools for modeling human diseases.
  • These cellular systems facilitate the study of developmental aspects of disease.
  • They hold promise for the development of personalized regenerative medicine strategies.