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Antihypertensive effect of bopindolol: a multi-centre study

E Török1, I Szám, G Buday

  • 1Department of Cardiology, Hungarian Institute of Cardiology, Budapest.

Journal of Human Hypertension
|August 1, 1990
PubMed

Insights

Bopindolol effectively lowers blood pressure in patients with essential hypertension. This study shows bopindolol monotherapy significantly reduces both systolic and diastolic blood pressure and heart rate.

Area of Science:

  • Cardiology
  • Pharmacology

Background:

  • Hypertension is a prevalent cardiovascular condition requiring effective management.
  • Nonselective beta-adrenergic receptor blockers are a cornerstone in hypertension treatment.
  • Bopindolol offers a long duration of action and intrinsic sympathomimetic activity.

Purpose of the Study:

  • To evaluate the efficacy of varying bopindolol monotherapy doses in patients with essential hypertension.
  • To assess the dose-response relationship of bopindolol in reducing blood pressure.

Main Methods:

  • A 14-week, single-blind, placebo-controlled trial involving 44 patients with mild to moderate essential hypertension.
  • Patients received bopindolol monotherapy, with doses titrated from 1 mg to a maximum of 2 mg daily.
  • Blood pressure, heart rate, ECG, and side effects were monitored bi-weekly.

Main Results:

  • Bopindolol significantly reduced supine systolic and diastolic blood pressure compared to placebo at 4, 8, and 12 weeks (P < 0.01).
  • Supine heart rate was also significantly lowered by bopindolol treatment (P < 0.01).
  • Dose-dependent reductions in blood pressure were observed, with the 2 mg dose showing the greatest effect.

Conclusions:

  • Bopindolol monotherapy is an effective treatment for essential hypertension.
  • The drug demonstrates a favorable safety profile with significant reductions in blood pressure and heart rate.
  • Titration of bopindolol dosage allows for effective blood pressure normalization in hypertensive patients.

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