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Cirrhosis is a chronic, irreversible liver disease characterized by the widespread replacement of healthy liver tissue with fibrotic scar tissue and the formation of regenerative nodules.Etiology of cirrhosisCirrhosis results from sustained liver injury that triggers progressive fibrosis and structural remodeling. The underlying causes are diverse, encompassing common and less frequent clinical conditions. Regardless of the origin, all causes lead to chronic inflammation, hepatocyte loss, and...
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Related Experiment Video

Updated: Jun 19, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
04:44

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

Sexual activity and functioning in female scleroderma patients.

A J Impens1, J Rothman, E Schiopu

  • 1University of Michigan Scleroderma Program, Ann Arbor, MI 48106-5753, USA. aimpens@med.umich.edu

Clinical and Experimental Rheumatology
|October 3, 2009
PubMed
Summary
This summary is machine-generated.

Systemic sclerosis (SSc) patients report sexual activity despite challenges. Scleroderma impacts sexual functioning, but many issues can be addressed in healthcare settings.

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Last Updated: Jun 19, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
04:44

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

Area of Science:

  • Rheumatology
  • Sexual Medicine
  • Patient-Reported Outcomes

Background:

  • Systemic sclerosis (SSc) is a chronic autoimmune disease with limited research on its impact on female sexual health.
  • Understanding patient-reported sexual activity and functioning is crucial for comprehensive SSc care.

Purpose of the Study:

  • To investigate the impact of SSc on sexual activity and functioning in female patients.
  • To identify factors influencing sexual activity and difficulties in women with SSc.

Main Methods:

  • A cohort of 101 female SSc patients completed validated questionnaires: SF-36, FSFI, and FSFS.
  • Patient-reported sexual activity, functioning scores, and contributing factors were analyzed.

Main Results:

  • 59.4% of SSc patients reported being sexually active; scleroderma was rarely the primary reason for inactivity.
  • Sexually active patients had significantly lower Female Sexual Functioning Index (FSFI) scores compared to the general population.
  • Sexual functioning correlated with mental health (SF-36 MCS) but not physical health (SF-36 PCS), age, or disease duration. Fatigue, pain, vaginal dryness, and discomfort were key issues.

Conclusions:

  • Women with SSc maintain sexual activity despite physical and psychological challenges.
  • Disease-related issues significantly impact sexual functioning but are often manageable.
  • Healthcare providers should proactively address sexual health concerns during routine SSc patient visits.