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Solid state investigation and characterization of the polymorphic and pseudopolymorphic forms of indapamide
Pradeep Ghugare1, Vaijanath Dongre, Pravin Karmuse
1Nadkarni Sacasa Research Laboratory, Department of Chemistry, St. Xavier's College, Mumbai 400001, India. p d ghugare@yahoo.com
Journal of Pharmaceutical and Biomedical Analysis
|October 3, 2009
Summary
This study investigated indapamide, a hypertension drug, revealing distinct polymorphic and pseudopolymorphic forms. Understanding these crystalline structures is crucial for drug formulation and efficacy.
Area of Science:
- Pharmaceutical Sciences
- Solid-State Chemistry
- Drug Development
Background:
- Indapamide is a widely prescribed diuretic for hypertension.
- Understanding the solid-state properties of indapamide is essential for its pharmaceutical development.
- Polymorphism can significantly impact drug bioavailability and stability.
Purpose of the Study:
- To conduct a comprehensive solid-state investigation of indapamide.
- To perform polymorphic screening to identify different crystalline forms.
- To characterize the identified polymorphic and pseudopolymorphic forms of indapamide.
Main Methods:
- X-ray powder diffraction (XRPD) for crystal structure analysis.
- Spectroscopic techniques like DRIFT for molecular characterization.
- Thermal analysis including DSC and TGA for thermal behavior.
- NMR spectroscopy and HS-GC for solvent stoichiometry determination.
Main Results:
- Confirmation of one polymorphic and three pseudopolymorphic forms of indapamide.
- Significant differences in solid-state properties among the identified forms.
- Detailed characterization data for each crystalline form.
- Calculation of solvent ratios in pseudopolymorphs using multiple analytical techniques.
Conclusions:
- Indapamide exhibits complex solid-state behavior with multiple crystalline forms.
- The identified forms possess distinct properties requiring specific handling during formulation.
- This research provides critical data for optimizing indapamide-based pharmaceutical products.
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