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Updated: Jun 19, 2026
11:27
A Guide to Production, Crystallization, and Structure Determination of Human IKK1/α
Published on: November 2, 2018
Keeping IGF-II under control: lessons from the IGF-II-IGF2R crystal structure
James Brown1, E Yvonne Jones, Briony E Forbes
1Cancer Research UK Receptor Structure Research Group, Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Headington, Oxford, OX3 7BN, UK.
Trends in Biochemical Sciences
|October 3, 2009
Summary
Insulin-like growth factor-II (IGF-II) is regulated by multiple proteins. The crystal structure reveals IGF-II shares a binding site for IGF-II receptors (IGF2R) and IGF binding proteins (IGFBPs).
Area of Science:
- Endocrinology
- Molecular Biology
- Structural Biology
Background:
- Insulin-like growth factor-II (IGF-II) is crucial for cell growth, survival, migration, and differentiation.
- Regulation of IGF-II expression and activity is essential.
- The type 1 IGF receptor (IGF-1R) mediates IGF-II signaling.
Purpose of the Study:
- To elucidate the structural basis of IGF-II regulation.
- To understand the interaction between IGF-II, IGF2R, and IGFBPs.
Main Methods:
- X-ray crystallography to determine the structure of the IGF-II-IGF2R complex.
Main Results:
- The crystal structure of the IGF-II-IGF2R complex was elucidated.
- A common binding surface on IGF-II for IGF2R and IGFBPs was identified.
Conclusions:
- IGF-II regulation involves shared binding sites for its key interacting proteins.
- This structural insight aids in understanding IGF-II's role in biological processes.
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