Related Experiment Video
Updated: Jun 19, 2026
Preparation and Evaluation of 99mTc-labeled Tridentate Chelates for Pre-targeting Using Bioorthogonal Chemistry
Published on: February 4, 2017
Synthesis and biodistribution of a novel (99m)Tc nitrido dithiocarbamate complex containing aromatic group for
Junbo Zhang1, Xiao Lin, Jialei Ren
1Key Laboratory of Radiopharmaceuticals (Beijing Normal University), Ministry of Education, College of Chemistry, Beijing Normal University, Beijing 100875, PR China. zhjunbo@bnu.edu.cn
Abstract:
In the present study, the N-benzyl dithiocarbamate (BZDTC) was synthesized and radiolabeled with [(99m)TcN](2+) intermediate to form the bis(N-benzyl dithiocarbamato) nitrido technetium-99m complex [(99m)TcN(BZDTC)(2)]. The radiochemical purity of the complex was over 90% by thin layer chromatography (TLC) and high performance liquid chromatography (HPLC). It was stable over 6h at room temperature. The partition coefficient and electrophoresis results indicated that this complex was lipophilic and neutral. Biodistribution in mice showed that the complex accumulated in the brain with high uptake. The brain uptake (ID%/g) was 1.87, 1.21 and 0.85 and the brain/blood ratio was 0.75, 1.55 and 1.12 at 5, 30 and 60min post-injection, respectively. These results suggest that this complex could be a potential brain perfusion imaging agent.
![Technical Aspect of the Automated Synthesis and Real-Time Kinetic Evaluation of [11C]SNAP-7941](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F59557.jpg&w=3840&q=50)
