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Technique of Conjunctival Biopsy and Direct Immunofluorescence for Diagnosing Mucous Membrane Pemphigoid
Published on: June 17, 2025
Bullous pemphigoid and internal diseases - A case-control study.
Hana Jedlickova1, Milos Hlubinka, Tomas Pavlik
1Ist Department of Dermatovenereology, Masaryk University, St. Anna Faculty Hospital, 656 91, Brno, Czech Republic. hana.jedlickova@fnusa.cz
European Journal of Dermatology : EJD
|October 3, 2009
Summary
Bullous pemphigoid (BP) is significantly associated with neurological diseases, particularly in individuals over 80. This study highlights a strong link between neurological conditions like stroke and dementia and the onset of BP.
Area of Science:
- Dermatology
- Neurology
- Epidemiology
Background:
- Bullous pemphigoid (BP) is an autoimmune blistering disease.
- The association between BP and internal diseases requires further investigation.
Purpose of the Study:
- To investigate the association between bullous pemphigoid and selected internal diseases.
- To identify specific internal diseases that may increase the risk of developing BP.
Main Methods:
- Retrospective case-control study.
- 89 BP patients were matched with 89 controls.
- Unconditional logistic regression and maximum likelihood tests were used.
Main Results:
- A statistically significant association was found between bullous pemphigoid and neurological diseases (p=0.001).
- Neurological disease was present in 42.7% of BP patients versus 19.1% of controls.
- Elderly patients (>=80 years) with neurological disease had a significantly higher risk of BP (OR 10.55).
- Cerebral stroke and dementia were the most frequent neurological conditions.
Conclusions:
- Neurological diseases, including stroke and dementia, are significantly associated with bullous pemphigoid.
- The risk of BP is substantially increased in elderly patients with co-existing neurological conditions.
- No significant associations were found for other investigated internal diseases.
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