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Power01:08

Power

The concept of work involves force and displacement; meanwhile, the work-energy theorem relates the net work done on a body to the difference in its kinetic energy, calculated between two points on its trajectory. While none of these quantities or relations involves time explicitly, we know that the time available to accomplish work is often just as important as the amount of work itself. For example, sprinters in a race may have achieved the same velocity at the finish, therefore,...
Instantaneous Power01:22

Instantaneous Power

Instantaneous power is important in electrical circuits, mainly when dealing with sinusoidal input. Instantaneous power, denoted as p(t), results from the multiplication of the instantaneous voltage (v(t)) across an element and the instantaneous current (i(t)) flowing through it. This relationship adheres to the passive sign convention and represents a fundamental principle in electrical engineering.
Turbine-Governor Control01:17

Turbine-Governor Control

Turbine-governor control is crucial for maintaining power system stability by balancing turbine mechanical power output with electrical load demand. This mechanism ensures that generator frequency and rotor speed are within acceptable limits during load variations. Turbine-generator units store kinetic energy due to their rotating masses; this energy is released to meet the load requirement when the load increases. The electrical torque of turbines rises to meet the demand, whereas the...
Average Power01:13

Average Power

In practical electrical applications, the concept of time-varying instantaneous power is not frequently utilized. Instead, focus shifts to the more practical quantity known as average power. Average power is determined by integrating the instantaneous power over a specified time period and subsequently dividing it by that duration.
Midrange01:07

Midrange

A somewhat easy to compute quantitative estimate of a data set’s central tendency is its midrange, which is defined as the mean of the minimum and maximum values of an ordered data set.
Simply put, the midrange is half of the data set’s range. Similar to the mean, the midrange is sensitive to the extreme values and hence the prospective outliers. However, unlike the mean, the midrange is not sensitive to all the values of the data set that lie in the middle. Thus, it is prone to outliers and...
Torque01:10

Torque

Torque is an important quantity for describing the dynamics of a rotating rigid body. We see the application of torque in many ways in the world, such as when pressing the accelerator in a car, which causes the engine to apply additional torque on the drivetrain. Here, we define torque and provide a framework to create an equation to calculate torque for a rigid body with fixed-axis rotation.
Torque can be considered as the rotational counterpart to force. Since forces change the translational...

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Related Experiment Video

Updated: Jun 19, 2026

A 100 KW Class Applied-field Magnetoplasmadynamic Thruster
11:47

A 100 KW Class Applied-field Magnetoplasmadynamic Thruster

Published on: December 22, 2018

STAT3 revs up the powerhouse.

Nancy C Reich1

  • 1Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, NY 11794, USA. nancy.reich@stonybrook.edu

Science Signaling
|October 3, 2009
PubMed
Summary
This summary is machine-generated.

Signal transducer and activator of transcription 3 (STAT3) serine phosphorylation enhances mitochondrial oxidative phosphorylation and promotes cellular transformation, independent of its nuclear functions.

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Optimization, Test and Diagnostics of Miniaturized Hall Thrusters
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Last Updated: Jun 19, 2026

A 100 KW Class Applied-field Magnetoplasmadynamic Thruster
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Optimization, Test and Diagnostics of Miniaturized Hall Thrusters
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Area of Science:

  • Molecular Biology
  • Cell Biology
  • Biochemistry

Background:

  • Signal transducers and activators of transcription (STATs) are typically activated by tyrosine phosphorylation, leading to nuclear translocation and gene regulation.
  • STAT3, a key member of the STAT family, has known nuclear functions but potential extranuclear roles are less understood.

Purpose of the Study:

  • To investigate the extranuclear functions of STAT3.
  • To explore the role of STAT3 serine phosphorylation in cellular processes beyond gene transcription.

Main Methods:

  • Investigated STAT3 modifications, specifically serine phosphorylation.
  • Assessed the impact of modified STAT3 on mitochondrial function and cellular transformation.
  • Utilized oncogenic Ras as a model for cellular transformation.

Main Results:

  • STAT3 serine phosphorylation was found to augment mitochondrial oxidative phosphorylation.
  • This serine-phosphorylated STAT3 supported cellular transformation induced by oncogenic Ras.
  • These effects were observed independently of STAT3's classical nuclear role.

Conclusions:

  • STAT3 possesses extranuclear functions mediated by serine phosphorylation.
  • Serine-phosphorylated STAT3 plays a significant role in mitochondrial metabolism and cellular transformation.
  • STAT3 is a multifunctional protein involved in both nuclear and cytoplasmic/mitochondrial pathways.