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Related Experiment Video

Updated: Jun 19, 2026

Assessment of Audio-Tactile Sensory Substitution Training in Participants with Profound Deafness Using the Event-Related Potential Technique

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Published on: September 7, 2022

Non-verbal sound processing in the primary progressive aphasias.

Johanna C Goll¹, Sebastian J Crutch, Jenny H Y Loo

¹Dementia Research Centre, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK.

Brain : a Journal of Neurology

|October 3, 2009

Summary

Primary progressive aphasias impair non-verbal sound processing. Patients with progressive non-fluent aphasia and semantic dementia showed deficits in auditory perception and recognition, varying by syndrome.

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Area of Science:

Neuroscience
Neurology
Psychology

Background:

The processing of non-verbal sounds is not well understood in primary progressive aphasias (PPA).
Primary progressive aphasias encompass conditions like progressive non-fluent aphasia (PNFA) and semantic dementia (SD).

Purpose of the Study:

To investigate complex non-verbal sound processing in patients with primary progressive aphasia.
To differentiate auditory processing deficits in progressive non-fluent aphasia and semantic dementia.

Main Methods:

Developed a novel neuropsychological battery for complex sound processing at perceptual, apperceptive, and semantic levels.
Utilized within-modality response procedures and visual modality matching tests.
Studied 20 patients with primary progressive aphasia (12 PNFA, 8 SD) and age-matched controls.

Main Results:

Patients with primary progressive aphasia exhibited significant non-verbal sound analysis deficits compared to controls.
Auditory perceptual deficits were more prevalent in progressive non-fluent aphasia.
Apperceptive and semantic processing deficits were observed in both progressive non-fluent aphasia and semantic dementia, with distinct patterns.

Conclusions:

Core disorders of complex non-verbal sound perception and recognition exist in primary progressive aphasia.
Specific perceptual and semantic level deficits in cortical auditory processing are associated with progressive non-fluent aphasia and semantic dementia, respectively.