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Updated: Jun 19, 2026

Hollow Fiber Bioreactors for In Vivo-like Mammalian Tissue Culture
Published on: May 26, 2016
[Dynamic membrane bioreactor with glass fiber tube covered with organic membrane]
Dong-dong Yuan1, Yao-bo Fan, Guo-liang Xu
1Department of Water Pollution Control Technology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China. yuandd_0@163.com
Abstract:
A novel grille form complex membrane module composed of glass fiber covered with organic membrane and the dynamic membrane bioreactor (DMBR) with this complex membrane were studied. The results showed that the flux of the dynamic membrane of glass fiber tube without covering with organic membrane solution was only 4 L/(m2 x h) at a trans-membrane pressure (TMP) of 0.02 MPa. After the modification of covering with the organic membrane solution, the complex dynamic membrane flux could reach to a level of 16 L/(m2 x h) at a TMP of 0.01 MPa in operation, and after a hydraulic and chemical cleaning, the membrane flux was up to 17.1 L/(m2 x h) at a lower TMP of 0.003 MPa. When the glass fiber tube was coated with a membrane solution with a concentration of 1:4 (membrane materials/solution in volume ratio), the flux of the complex membrane worked steadily at 14.29 L/(m2 x h) more than 51 days, and according to calculation by TMP rising, the flux could maintain for almost 275 d. The average removal rates of COD and NH4+ -N were 81.96% and 83.66% respectively by the DMBR, and that were 21.01% and 3.61% only by the complex dynamic membrane. Moreover, the cost of complex membrane was approximately 40-60 yuan/m2, which was lower than the traditional organic membrane.
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