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Extrusion-spheronization: process variables and characterization.

V R Sinha1, M K Agrawal, A Agarwal

  • 1University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, India. sinha_vr@rediffmail.com

Critical Reviews in Therapeutic Drug Carrier Systems
|October 6, 2009
PubMed
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Extrusion-spheronization is a key pelletization technique for drug delivery, offering high drug loading and cost-effectiveness. This review details process variables and quality evaluation methods for optimized multiparticulate systems.

Area of Science:

  • Pharmaceutical Sciences
  • Materials Science

Background:

  • Multiparticulate systems are advanced drug delivery vehicles with evolving applications.
  • Pelletization techniques have significantly advanced, with extrusion-spheronization emerging as a leading method.

Purpose of the Study:

  • To review the extrusion-spheronization process for multiparticulate drug delivery.
  • To identify operational and formulation variables impacting pellet quality.
  • To discuss methods for evaluating final pellet characteristics.

Main Methods:

  • Focus on extrusion-spheronization as a pelletization technique.
  • Analysis of operational variables: extruder types, screen pressure, screw speed, temperature, moisture content.
  • Examination of formulation variables: excipients and drug properties.

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  • Discussion of pellet quality evaluation methods: size, shape, friability, strength, density, porosity, flow, and texture.

    • Main Results:

    • Extrusion-spheronization enables high active ingredient loading and narrow particle size distribution.
    • Process parameters significantly influence pellet quality attributes.
    • Coating can enhance site-specific delivery and drug bioavailability.

    Conclusions:

    • Extrusion-spheronization is a versatile and cost-effective method for producing high-quality multiparticulate drug delivery systems.
    • Careful control of operational and formulation parameters is crucial for optimizing pellet characteristics.
    • Further research into specialized coating techniques can improve drug targeting and efficacy.