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Related Concept Videos

Acute Pyelonephritis II: Diagnostic Studies and Management01:28

Acute Pyelonephritis II: Diagnostic Studies and Management

Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
Acute Respiratory Failure-V01:29

Acute Respiratory Failure-V

The treatment for acute respiratory failure varies based on factors like the underlying cause, overall health, and severity. A collaborative healthcare team is essential for early detection, often through arterial blood gas analysis. Identifying the cause is the primary goal, with treatment strategies adjusted for ventilation/perfusion (V/Q) mismatch, shunting, or diffusion impairment.
Ensure that patients are monitored continuously for their response to therapy, including changes in...
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Pneumonia IV: Management

The treatment of pneumonia varies based on its severity and the causative pathogen. Here is a structured approach to managing pneumonia, integrating pharmaceutical and supportive care strategies.
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For bacterial pneumonia, antibiotics serve as the cornerstone of therapy. Initial treatment often begins with empirical antibiotics, tailored to the anticipated causative organism and adjusted based on culture results. Key antibiotic choices include:
Acute Coronary Syndrome V: Nursing Management01:26

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Nursing Assessment:Nursing management of acute coronary syndrome (ACS) involves taking the patient's history, focusing on primary complaints such as chest pain, dyspnea, and excessive sweating (diaphoresis), as well as other symptoms like back or jaw pain, nausea, vomiting, palpitations, dizziness, and fatigue. The nurse also reviews the patient's history of cardiac events, risk factors such as hypertension, diabetes, smoking, family history, and current medications.In the objective assessment,...
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Related Experiment Video

Updated: Jun 19, 2026

Use of Animal Model of Sepsis to Evaluate Novel Herbal Therapies
07:34

Use of Animal Model of Sepsis to Evaluate Novel Herbal Therapies

Published on: April 11, 2012

Antioxidant therapy in critically septic patients.

S Rinaldi1, F Landucci, A R De Gaudio

  • 1Department of Critical Care, University of Florence, 50134 Florence Italy.

Current Drug Targets
|October 6, 2009
PubMed
Summary

Critical illness causes redox imbalance, increasing oxidative stress. Antioxidant therapies, including selenium, glutamine, and omega-3 fatty acids, show promise in improving outcomes for critically ill patients.

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Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
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Published on: August 30, 2018

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Last Updated: Jun 19, 2026

Use of Animal Model of Sepsis to Evaluate Novel Herbal Therapies
07:34

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Published on: April 11, 2012

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
11:17

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

Published on: August 30, 2018

Area of Science:

  • Critical care medicine
  • Biochemistry
  • Molecular biology

Background:

  • Critical illness and sepsis induce significant redox imbalance due to increased oxidants and decreased antioxidant defenses.
  • Sources of oxidative stress in critical patients include mitochondrial dysfunction, neutrophil activation, and arachidonic acid metabolism.
  • Endogenous antioxidants like superoxide dismutases, glutathione peroxidase, uric acid, and bilirubin play crucial roles.

Purpose of the Study:

  • To review the role of oxidative stress in critical illness.
  • To evaluate the efficacy of antioxidant therapies in critical care.
  • To identify promising antioxidant molecules and future research directions.

Main Methods:

  • Review of prospective randomized clinical trials on antioxidant therapy in critical illness.
  • Analysis of evidence supporting selenium, glutamine, and omega-3 fatty acids.
  • Discussion of potential roles for melatonin and vitamin C.

Main Results:

  • Selenium supplementation may improve outcomes regarding infections and organ failure.
  • Glutamine is associated with reduced infectious complications.
  • Omega-3 fatty acids show potential efficacy, particularly in sepsis.

Conclusions:

  • Antioxidant therapy holds promise for critical illness, with specific agents demonstrating benefits.
  • Further research is needed to optimize combinations, dosages, and timing of antioxidant administration.
  • Establishing clear protocols will lead to more definitive results in antioxidant therapy for critical conditions.