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Beta-globin gene haplotypes in Polynesians are predominantly southern Chinese in type
R J Trent1, V Ferguson, M S Hertzberg
1Molecular Biology Laboratory, University of Sydney, NSW, Australia.
Human Heredity
|January 1, 1990
Abstract:
beta-Globin gene haplotypes obtained in Polynesian Samoans were similar to those described in Southern Chinese. An atypical HindIII restriction fragment length polymorphism detected with pRK29, a 3' beta-globin gene probe, was present at a gene frequency of 7% in Samoans. Haplotype patterns suggest that this polymorphism may have arisen by 1 or 2 mutational events. DNA haplotypes derived from the beta-globin gene cluster confirm nuclear and mitochondrial DNA data that Polynesian precursor populations were East Asian in origin.