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Published on: December 29, 2015
Molecular epidemiology of Japanese encephalitis in East Asia
1Department of Virology, Institute of Tropical Medicine, Nagasaki University, GCOE Program, 1-12-4 Sakamoto, Nagasaki 852-8523, Japan. moritak@nagasaki-u.ac.jp
Abstract:
Japanese encephalitis virus is genetically divided into five genotypes. Until the early 1990s, only genotype-3 JE virus was identified in Japan, then, the genotype shifted to type-1 countrywide. Based on our molecular epidemiological study of JEV in Vietnam, China, and Japan, 8 subgroups of genotype 1 JEVs are circulating in East Asia and, at least, 4 of these subgroups are chronologically related and frequently introduced to Japan through China. Possibly, this subgroup distribution is due to bird migration and/or infected mosquitoes which carry viruses for long distances. While in Japan, a small population of genotype 1 is circulating locally.
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