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Home-Based Monitor for Gait and Activity Analysis

Home-Based Monitor for Gait and Activity Analysis

Published on: August 8, 2019

Gait analysis using accelerometry in dystrophin-deficient dogs.

Inès Barthélémy¹, Eric Barrey, Jean-Laurent Thibaud

¹Laboratoire de Neurobiologie, Ecole Nationale Vétérinaire d'Alfort, 94704 Maisons-Alfort, France.

Neuromuscular Disorders : NMD

|October 6, 2009

Summary

Accelerometry reliably quantifies gait abnormalities in Golden Retriever Muscular Dystrophy (GRMD) dogs, mirroring Duchenne muscular dystrophy (DMD). This inexpensive tool aids pre-clinical trial locomotion assessments.

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Area of Science:

Biomechanical analysis
Animal models of neuromuscular disease
Locomotion studies

Background:

Golden Retriever Muscular Dystrophy (GRMD) dogs share clinical similarities with human Duchenne muscular dystrophy (DMD) patients, particularly gait impairments.
Objective gait assessment is crucial for evaluating disease progression and therapeutic efficacy in GRMD models.

Purpose of the Study:

To evaluate the utility and reliability of accelerometry for assessing gait in GRMD dogs.
To identify specific gait variables altered in GRMD dogs using accelerometry.

Main Methods:

Three-axial accelerometry was used to record gait data in 11 GRMD dogs and 8 healthy controls over three sessions.
Key gait variables including power, force, regularity, stride length, speed, and frequency were calculated and normalized.

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Main Results:

GRMD dogs exhibited significantly decreased total power, force, regularity, stride length, speed, and cranio-caudal power.
GRMD dogs showed significantly increased medio-lateral power.
Accelerometry-derived gait variables demonstrated high repeatability within and between assessment sessions.

Conclusions:

Accelerometry provides reliable and objective quantitative data on the characteristic slow, short-stepped, and swaying gait of GRMD dogs.
The ease of setup, speed, and low cost make accelerometry a valuable tool for locomotion assessment in pre-clinical trials for muscular dystrophy.